(2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

Base Information

Chemical Name:(2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol
CAS No.:1598413-57-0
Molecular Formula:C₃₅H₄₈O₅Si
Molecular Weight:576.849
Hs Code.:

Synonyms:(2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

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Chemical Property of (2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

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Technology Process of (2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

There total 7 articles about (2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₅₀O₆Si

: 1598413-57-0
(2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: With potassium carbonate; In methanol; for 3h;
DOI:10.1021/ol500875e

Reference yield:

: 1598413-56-9
(4S,6R)-7-(tert-butyldiphenylsilyloxy)-6-methylhept-1-en-4-yl 3-(4-methoxybenzyloxy) propanoate

: 1598413-57-0
(2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C / Inert atmosphere

2: dmap; pyridine / dichloromethane; toluene / 14 h / -78 °C / Inert atmosphere

3: acetic acid; boron trifluoride diethyl etherate / hexane / 2 h / 0 °C / Inert atmosphere

4: potassium carbonate / methanol / 3 h

With pyridine; dmap; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; acetic acid; In methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol500875e

Reference yield:

: 1598413-55-8
(4S,6R)-7-(tert-butyldiphenylsilyloxy)-6-methylhept-1-en-4-ol

: 1598413-57-0
(2R,4S,6S)-2-((R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropyl)-6-(2-(4-methoxybenzyloxy)ethyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C / Inert atmosphere

3: dmap; pyridine / dichloromethane; toluene / 14 h / -78 °C / Inert atmosphere

4: acetic acid; boron trifluoride diethyl etherate / hexane / 2 h / 0 °C / Inert atmosphere

5: potassium carbonate / methanol / 3 h

With pyridine; dmap; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; In methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol500875e