N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine

Base Information

• Chemical Name: N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine
• CAS No.: 81585-13-9
• Molecular Formula: C₁₉H₂₀N₄O₂
• Molecular Weight: 336.393

Synonyms:N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine

Chemical Property of N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine

There total 3 articles about N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyl-2,3-dihydro-1H-benz[de]isoquinoline; hydrochloride (22817-39-6) → N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine (81585-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10percent Pd/C / aq. ethanol / 3 h / 2062.7 Torr

2: Na/liquid NH₃ / Heating

3: toluene / 3 h / Heating

With ammonia; hydrogen; sodium; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1021/jm00348a020

Reference yield:

2,3-dihydro-1H-benzisoquinoline hydrochloride (32386-87-1) → N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine (81585-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Na/liquid NH₃ / Heating

2: toluene / 3 h / Heating

With ammonia; sodium; In toluene;

DOI:10.1021/jm00348a020

Reference yield:

1-<4-Nitro-phenyl>-S-methyl-isothioharnstoff (27806-77-5) + 2,3,3a,4,5,6-hexahydro-1H-benzisoquinoline (71960-94-6) → N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine (81585-13-9)

Guidance literature:

In toluene; for 3h; Heating;

DOI:10.1021/jm00348a020

upstream raw materials:

1-<4-Nitro-phenyl>-S-methyl-isothioharnstoff

2,3,3a,4,5,6-hexahydro-1H-benzisoquinoline

2-benzyl-2,3-dihydro-1H-benz[de]isoquinoline; hydrochloride

2,3-dihydro-1H-benzisoquinoline hydrochloride

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