(S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

Base Information

Chemical Name:(S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one
CAS No.:916588-60-8
Molecular Formula:C₂₁H₂₅NO₅S
Molecular Weight:403.499
Hs Code.:

Synonyms:(S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

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Technology Process of (S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

There total 1 articles about (S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 916588-53-9
2-(1-benzyloxypropyl)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-4-one

: 916588-60-8
(S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

Guidance literature:: With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2006.09.004

Reference yield: 94.0%

: 916588-60-8
(S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

: 916588-54-0
4-benzyloxy-3-[(4-methylphenyl)sulfonylamino]hexan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tet.2006.09.004

Reference yield:

: 916588-60-8
(S)-4-((R)-1-Benzyloxy-propyl)-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one

: 495-20-5
(+)-conhydrine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 94 percent / lithium aluminum hydride / tetrahydrofuran / 0 - 20 °C

2.1: 96 percent / imidazole / dimethylformamide / 2 h / 20 °C

3.1: 97 percent / sodium hydride / dimethylformamide

4.1: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 h / 20 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

6.2: 82 percent / tetrahydrofuran; hexane / 2 h / -78 °C

7.1: 92 percent / Grubbs' second generation catalyst / CH₂Cl₂ / 2 h / Heating

8.1: 94 percent / hydrogen / Pd/C / ethanol / 10 h / 20 °C

9.1: 80 percent / sodium amalgam; sodium phosphate / methanol / 5 h / 20 °C

With 1H-imidazole; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium phosphate; pyridinium chlorochromate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.09.004