methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

Base Information

• Chemical Name: methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate
• CAS No.: 1268729-57-2
• Molecular Formula: C₃₀H₄₈N₄O₈
• Molecular Weight: 592.733
• Mol file: 1268729-57-2.mol

Synonyms:methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

Chemical Property of methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

There total 11 articles about methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl N-[(tert-butoxy)carbonyl]-N-methyl-D-valyl-N-methyl-D-alaninate (1268729-55-0) + methyl (2R)-2-(methylamino)propanoate hydrochloride → methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate (1268729-57-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1002/hlca.201100437

Reference yield: 7.0%

Boc-Lys(Z)-OH (2389-45-9) + C11H22N2O3*ClH (1268729-56-1) → methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate (1268729-57-2) + (3R,6R)-1,3,4-trimethyl-6-(1-methylethyl)piperazine-2,5-dione (1384345-06-5)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1002/hlca.201100437

Reference yield:

(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-methylbutanoic acid (13850-91-4,45170-31-8,89536-85-6) → methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate (1268729-57-2)

Guidance literature:

Multi-step reaction with 4 steps

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

3: water; lithium hydroxide / tetrahydrofuran

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran;

DOI:10.3390/md10061307

upstream raw materials:

methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate

N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine

Boc-Lys(Z)-OH

Boc-D-Val-OH

Downstream raw materials:

C₂₉H₄₆N₄O₈

(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide