(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

Base Information

Chemical Name:(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide
CAS No.:1384935-32-3
Molecular Formula:C₂₉H₄₀N₄O₅
Molecular Weight:524.66
Hs Code.:

(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

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Suppliers and Price of (2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

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Chemical Property of (2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

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Technology Process of (2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

There total 8 articles about (2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1268729-67-4
(3R,6R,9R)-9-amino-3,4,7-trimethyl-6-(1-methylethyl)-1,4,7-triazacyclotridecane-2,5,8-trione

: (2E)-3-[4-(buta-2,3-dienyl-1-oxy)-phenyl]prop-2-enoic acid

: 1384935-32-3
(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; Inert atmosphere; Cooling with ice;
DOI:10.1002/hlca.201100437

Reference yield:

: 1268729-65-2
(3R,6R,9R)-9-{[(tert-butoxy)carbonyl]amino}-3,4,7-trimethyl-6-(1-methylethyl)-1,4,7-triazacyclotridecane-2,5,8-trione

: 1384935-32-3
(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere; Cooling with ice

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100437

Reference yield:

: 1268729-57-2
methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

: 1384935-32-3
(2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3R,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide / tetrahydrofuran; water / 0 °C

2: palladium 10% on activated carbon; hydrogen / ethanol

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 51 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C

5: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere; Cooling with ice

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100437