3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

Base Information

Chemical Name:3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide
CAS No.:212578-61-5
Molecular Formula:C₂₈H₃₂N₂O₄
Molecular Weight:460.573
Hs Code.:

Synonyms:3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

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Chemical Property of 3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

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Technology Process of 3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

There total 3 articles about 3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 212578-60-4
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid

: 212578-61-5
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm970795t

Reference yield:

: (E)-3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-acrylic acid ethyl ester

: 212578-61-5
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Raney Ni / ethanol; H₂O / 4 h / 20 °C / 2585.7 Torr

2: 98 percent / KOH / ethanol / Heating

3: 83 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In ethanol; dichloromethane; water;
DOI:10.1021/jm970795t

Reference yield:

: 212578-72-8
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid ethyl ester

: 212578-61-5
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)N-[2-(3,4-dimethoxyphenyl)ethyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / KOH / ethanol / Heating

2: 83 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm970795t