2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

Base Information

Chemical Name:2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene
CAS No.:1388707-76-3
Molecular Formula:C₁₆H₂₂F₂O₃
Molecular Weight:300.346
Hs Code.:

Synonyms:2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

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Chemical Property of 2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

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Technology Process of 2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

There total 3 articles about 2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1388707-61-6
2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-iodoethene

: potassium (4-tert-butyl)phenyltrifluoroborate

: 1388707-76-3
2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In water; tert-butyl alcohol; at 90 ℃; for 18h;
DOI:10.1021/jo3011705

Reference yield:

: 130156-55-7
2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane

: 1388707-76-3
2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; zinc(II) chloride; lithium diisopropyl amide / tetrahydrofuran / 2 h / 0 - 15 °C

1.2: 0.17 h / 10 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; tert-butyl alcohol / 18 h / 90 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; water; tert-butyl alcohol; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo3011705

Reference yield:

: 123324-71-0
p-tert-butylphenylboronic acid

: 1388707-76-3
2,2-difluoro-1-(2'-methoxyethoxymethoxy)-1-(3''-tert-butylphenyl)ethene

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogen bifluoride / methanol; water / 2 h / 18 °C

2: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / water; tert-butyl alcohol / 18 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium hydrogen bifluoride; caesium carbonate; In methanol; water; tert-butyl alcohol; 2: Suzuki-Miyaura coupling;
DOI:10.1021/jo3011705