1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester
• CAS No.: 199330-54-6
• Molecular Formula: C₂₄H₄₂N₂O₅
• Molecular Weight: 438.608
• Mol file: 199330-54-6.mol

Synonyms:1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Chemical Property of 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester

There total 5 articles about 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarboxylic acid (199330-53-5) + methyl 1-amino-4,4-dimethylcyclohexanecarboxylate hydrochloride → 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester (199330-54-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 36h; Ambient temperature;

DOI:10.1016/S0957-4166(98)00235-3

Reference yield:

4,4-dimethylcyclohexenone (1073-13-8) → 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester (199330-54-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / (+)-limonene / Pd/C

2: ammonium carbonate / aq. ethanol / 55 - 60 °C

3: aq. NaOH / 72 h / Heating

4: HCl / 4 h / Heating

5: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 24 h / Ambient temperature

With ammonium carbonate; hydrogenchloride; sodium hydroxide; D-limonene; (+)-limonene; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/ja962905b

Reference yield:

4,4-dimethylcyclohexane-1-one (4255-62-3) → 1-[(1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarbonyl)-amino]-4,4-dimethyl-cyclohexanecarboxylic acid methyl ester (199330-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium carbonate / aq. ethanol / 55 - 60 °C

2: aq. NaOH / 72 h / Heating

3: HCl / 4 h / Heating

4: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 24 h / Ambient temperature

With ammonium carbonate; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

DOI:10.1021/ja962905b

upstream raw materials:

1-tert-Butoxycarbonylamino-4,4-dimethyl-cyclohexanecarboxylic acid

4,4-dimethylcyclohexenone

4,4-dimethylcyclohexane-1-one

1-Amino-4,4-dimethyl-cyclohexanecarboxylic acid