1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Base Information

Chemical Name:1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
CAS No.:72912-58-4
Molecular Formula:C₁₇H₁₈ClNO₃*ClH
Molecular Weight:356.249
Hs Code.:

Synonyms:1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

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Chemical Property of 1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

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Technology Process of 1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

There total 5 articles about 1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 72912-36-8
9-methyl-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

: 72912-58-4
1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: With hydrogenchloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; for 16h; Ambient temperature;
DOI:10.1021/jm00161a029

Reference yield:

: 46274-23-1
2-(3,4-dimethoxy-5-methylphenyl)ethan-1-amine

: 72912-58-4
1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: BH₃ / tetrahydrofuran / 0.5 h / Heating

2: TFA, 36 N aq. H₂SO₄ / 3.5 h / 25 °C

3: BBr₃ / CH₂Cl₂ / 3 h / 25 °C

4: 62 percent / DDQ, 9 N aq. HCl / acetonitrile / 16 h / Ambient temperature

With hydrogenchloride; sulfuric acid; borane; boron tribromide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm00161a029

Reference yield:

: 104114-04-7
N-[2-(3,4-dimethoxy-5-methylphenyl)ethyl]-2-(4'-methoxyphenyl)-2-hydroxyethylamine

: 72912-58-4
1-(4'-hydroxyphenyl)-7,8-dihydroxy-6-chloro-9-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: TFA, 36 N aq. H₂SO₄ / 3.5 h / 25 °C

2: BBr₃ / CH₂Cl₂ / 3 h / 25 °C

3: 62 percent / DDQ, 9 N aq. HCl / acetonitrile / 16 h / Ambient temperature

With hydrogenchloride; sulfuric acid; boron tribromide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; acetonitrile;
DOI:10.1021/jm00161a029