5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

Base Information

Chemical Name:5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride
CAS No.:603123-64-4
Molecular Formula:C₂₃H₂₂ClNO₃S*ClH
Molecular Weight:464.413
Hs Code.:

Synonyms:5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

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Chemical Property of 5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

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Technology Process of 5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

There total 11 articles about 5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603123-53-1
C₂₈H₃₀ClNO₅S

: 603123-64-4
5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 603125-59-3
(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 603123-64-4
5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 80 °C / Inert atmosphere

2: sodium chlorite; dihydrogen peroxide / water; acetonitrile / 20 °C / pH 4 / aq. phosphate buffer

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; sodium chlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; sodium carbonate; In 1,4-dioxane; water; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm800222k

Reference yield:

: 603122-93-6
C₂₈H₃₀ClNO₄S

: 603123-64-4
5-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphtahlenyl)-2-thiophenecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; dihydrogen peroxide / water; acetonitrile / 20 °C / pH 4 / aq. phosphate buffer

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; sodium chlorite; dihydrogen peroxide; In 1,4-dioxane; water; acetonitrile;
DOI:10.1021/jm800222k