3-Fluoro-5-hydroxypyridine

Base Information

Chemical Name:3-Fluoro-5-hydroxypyridine
CAS No.:209328-55-2
Molecular Formula:C5H4FNO
Molecular Weight:113.091
Hs Code.:29339900
European Community (EC) Number:640-428-0
DSSTox Substance ID:DTXSID10376561
Wikidata:Q69758946
Mol file:209328-55-2.mol

Synonyms:3-Fluoro-5-hydroxypyridine;209328-55-2;5-fluoropyridin-3-ol;5-Fluoro-3-pyridinol;5-FLUORO-3-HYDROXYPYRIDINE;3-Pyridinol, 5-fluoro-;MFCD03095199;5-fluoranylpyridin-3-ol;SCHEMBL322617;DTXSID10376561;IUFLFKASIHPKNZ-UHFFFAOYSA-N;BCP26892;BBL103685;STL557495;AKOS005137900;AB13569;AC-7013;CS-W003026;GS-6511;3-fluoro-5-hydroxypyridine, AldrichCPR;SY022138;A4548;AM20061679;F1020;FT-0650036;EN300-102031;5-Fluoropyridin-3-ol;A815030;W-206577

Suppliers and Price of 3-Fluoro-5-hydroxypyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Fluoro-5-hydroxypyridine
1g
$ 195.00

TCI Chemical
3-Fluoro-5-hydroxypyridine >98.0%(GC)
1g
$ 151.00

TCI Chemical
3-Fluoro-5-hydroxypyridine >98.0%(GC)
200mg
$ 51.00

SynQuest Laboratories
3-Fluoro-5-hydroxypyridine
1 g
$ 220.00

SynQuest Laboratories
3-Fluoro-5-hydroxypyridine
250 mg
$ 90.00

Matrix Scientific
3-Fluoro-5-hydroxypyridine 95+%
5g
$ 189.00

Matrix Scientific
3-Fluoro-5-hydroxypyridine 95+%
1g
$ 57.00

Matrix Scientific
3-Fluoro-5-hydroxypyridine 95+%
25g
$ 685.00

Labseeker
3-Fluoro-5-hydroxypyridine 98
50g
$ 692.00

Frontier Specialty Chemicals
3-Fluoro-5-hydroxypyridine 98%
1g
$ 350.00

Total 77 raw suppliers

Chemical Property of 3-Fluoro-5-hydroxypyridine

Chemical Property:

Vapor Pressure:0.000534mmHg at 25°C
Melting Point:161-164℃
Refractive Index:1.526
Boiling Point:303 °C at 760 mmHg
PKA:8.38±0.10(Predicted)
Flash Point:137 °C
PSA：33.12000
Density:1.325 g/cm³
LogP:0.92630
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:113.027691913
Heavy Atom Count:8
Complexity:78.8

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-5-hydroxypyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC=C1F)O
Uses 3-Fluoro-5-hydroxypyridine is used in the preparation of pyridine derivatives as thyroid hormone β receptor agonists.

Technology Process of 3-Fluoro-5-hydroxypyridine

There total 1 articles about 3-Fluoro-5-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 209328-55-2
3-fluoro-5-hydroxypyridine

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 24 h / Heating

2: 89 percent / aq. NH₃, CuSO₄*5H₂O / 20 h / 135 °C

3: 82 percent / NaNO₂, HF, pyridine / 1.5 h / 0 - 50 °C

4: 36 percent / HBr / acetic acid / 72 h / 60 °C

With pyridine; ammonium hydroxide; hydrogen fluoride; hydrogen bromide; copper(II) sulfate; sodium nitrite; In acetic acid; benzene;
DOI:10.1021/jm980170a

Reference yield: 81.0%

: 209328-55-2
3-fluoro-5-hydroxypyridine

: 847902-56-1
5-fluoro-2-nitropyridin-3-ol

Guidance literature:: With sulfuric acid; nitric acid; at 0 - 20 ℃;

Reference yield: 53.0%

: 668262-52-0
methyl 2-(bromomethyl)-5-chlorobenzoate

: 209328-55-2
3-fluoro-5-hydroxypyridine

: 868636-32-2
methyl 5-chloro-2-{[(5-fluoropyridin-3-yl)oxy]methyl}benzoate

Guidance literature:: 3-fluoro-5-hydroxypyridine; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.25h;

methyl 2-(bromomethyl)-5-chlorobenzoate; In N,N-dimethyl-formamide; at 20 ℃;