1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate
CAS No.:1089669-51-1
Molecular Formula:C₂₉H₃₁F₂N₅O₆S₂
Molecular Weight:647.724
Hs Code.:

1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

Synonyms:1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

There total 9 articles about 1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014613-45-6
[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]boronic acid

: 1089669-50-0
1,1-dimethylethyl 4-{[(6-chloro-3-pyridinyl)sulfonyl]amino}-1-piperidinecarboxylate

: 1089669-51-1
1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In isopropyl alcohol; at 120 ℃; for 0.583333h; Microwave irradiation;

Reference yield:

: C₂₀H₂₃BF₂N₂O₄S

: 1089669-51-1
1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran; hexanes / 0.17 h / -78 °C

2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol / 0.58 h / 120 °C / Microwave irradiation

With hydrogenchloride; water; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; hexanes; isopropyl alcohol;

Reference yield:

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 1089669-51-1
1,1-dimethylethyl 4-[({6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinyl}sulfonyl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 20 °C

2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol / 0.58 h / 120 °C / Microwave irradiation

With sodium hydrogencarbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; isopropyl alcohol;