tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate
• CAS No.: 1215081-84-7
• Molecular Formula: C₁₉H₂₁ClN₆O₂S
• Molecular Weight: 432.934
• Mol file: 1215081-84-7.mol

Synonyms:tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate

Chemical Property of tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate

There total 4 articles about tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(4,6-dichloropyrimidin-2-ylthio)phenylcarbamate (1215081-83-6) + 3-amino-5-methylpyrazole (31230-17-8) → tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate (1215081-84-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

(4-mercaptophenyl)carbamic acid tert-butyl ester (852448-31-8) → tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate (1215081-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / tert-butyl alcohol / 15 h / Reflux

2: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 4 h / 85 °C

With sodium acetate; N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

4-aminotiophenol (1193-02-8) → tert-butyl 4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenylcarbamate (1215081-84-7)

Guidance literature:

Multi-step reaction with 3 steps

1: ethyl acetate / 1 h / Cooling with ice

2: sodium acetate / tert-butyl alcohol / 15 h / Reflux

3: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 4 h / 85 °C

With sodium acetate; N-ethyl-N,N-diisopropylamine; sodium iodide; In ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

tert-butyl 4-(4,6-dichloropyrimidin-2-ylthio)phenylcarbamate

3-amino-5-methylpyrazole

(4-mercaptophenyl)carbamic acid tert-butyl ester

4-aminotiophenol

Downstream raw materials:

tert-butyl 4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenylcarbamate