N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Base Information

Chemical Name:N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide
CAS No.:529488-64-0
Molecular Formula:C₂₅H₂₈IN₃O₅
Molecular Weight:577.419
Hs Code.:

Synonyms:N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

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Chemical Property of N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

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Technology Process of N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

There total 12 articles about N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 61203-48-3
2-iodo-4,5-dimethoxybenzoic acid

: 529488-63-9
4-[[2-(N,N-diethylamino)ethyl]amino]-6,7-methylenedioxyquinoline

: 529488-64-0
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Guidance literature:: 2-iodo-4,5-dimethoxybenzoic acid; With oxalyl dichloride; In dichloromethane; for 4h; Reflux;

4-[[2-(N,N-diethylamino)ethyl]amino]-6,7-methylenedioxyquinoline; With triethylamine; In dichloromethane; for 2h; Reflux; Inert atmosphere;

Reference yield:

: 59134-89-3
8-chloro-2H-[1,3]dioxolo[4,5-g]quinoline

: 529488-64-0
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: phenol / 2.5 h / Heating

1.2: 8 percent / phenol / 20 h / Heating

2.1: 1.10 g / Et₃N / CH₂Cl₂ / 16 h / Heating

With triethylamine; phenol; In dichloromethane;
DOI:10.1021/jm049447z

Reference yield:

: 154504-43-5,35478-79-6
6,7-methylenedioxy-4-quinolone

: 529488-64-0
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-diethylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / POCl₃ / 2 h / Heating

2.1: phenol / 2.5 h / Heating

2.2: 8 percent / phenol / 20 h / Heating

3.1: 1.10 g / Et₃N / CH₂Cl₂ / 16 h / Heating

With triethylamine; trichlorophosphate; phenol; In dichloromethane;
DOI:10.1021/jm049447z