(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester
CAS No.:1262860-21-8
Molecular Formula:C₂₄H₂₃F₄N₅O₄
Molecular Weight:521.471
Hs Code.:

Synonyms:(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

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Chemical Property of (5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

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Technology Process of (5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

There total 12 articles about (5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262860-20-7
[5-(5-amino-2-fluoro-phenyl)-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl]-carbamic acid tert-butyl ester

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 1262860-21-8
(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1262860-11-6
[1-(2-fluoro-phenyl)-1-trifluoromethyl-but-3-enyl]-carbamic acid tert-butyl ester

: 1262860-21-8
(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride; sodium hydrogencarbonate; sodium tetrahydroborate; O₃ / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; oxygen

2: potassium carbonate; pyridine; DIPEA / hydrogenchloride; dichloromethane; 1,4-dioxane; methanol

3: potassium tert-butylate / ethyl acetate; tert-butyl alcohol; tetrahydrofuran

4: tetrahydrofuran

5: potassium carbonate / ammonia; methanol

6: potassium nitrate / sulfuric acid

7: DIPEA / dichloromethane; tetrahydrofuran

8: Pd on charcoal / ethanol; tetrahydrofuran

9: 1,2-dichloro-ethane; DIPEA / N,N-dimethyl-formamide

With pyridine; hydrogenchloride; sodium tetrahydroborate; O₃; DIPEA; potassium tert-butylate; sodium hydrogencarbonate; potassium carbonate; potassium nitrate; 1,2-dichloro-ethane; Pd on charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; ethanol; dichloromethane; sulfuric acid; ammonia; oxygen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 124004-75-7
α,α,α-trifluoro-2-fluoroacetophenone

: 1262860-21-8
(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: toluene; hexane

2: tetrahydrofuran

3: hydrogenchloride; sodium hydrogencarbonate; sodium tetrahydroborate; O₃ / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; oxygen

4: potassium carbonate; pyridine; DIPEA / hydrogenchloride; dichloromethane; 1,4-dioxane; methanol

5: potassium tert-butylate / ethyl acetate; tert-butyl alcohol; tetrahydrofuran

6: tetrahydrofuran

7: potassium carbonate / ammonia; methanol

8: potassium nitrate / sulfuric acid

9: DIPEA / dichloromethane; tetrahydrofuran

10: Pd on charcoal / ethanol; tetrahydrofuran

11: 1,2-dichloro-ethane; DIPEA / N,N-dimethyl-formamide

With pyridine; hydrogenchloride; sodium tetrahydroborate; O₃; DIPEA; potassium tert-butylate; sodium hydrogencarbonate; potassium carbonate; potassium nitrate; 1,2-dichloro-ethane; Pd on charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; ethanol; hexane; dichloromethane; sulfuric acid; ammonia; oxygen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;