5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

Base Information

Chemical Name:5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride
CAS No.:1262856-23-4
Molecular Formula:C₁₉H₁₅F₄N₅O₂*ClH
Molecular Weight:457.815
Hs Code.:

Synonyms:5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

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Chemical Property of 5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

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Technology Process of 5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

There total 12 articles about 5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262860-21-8
(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester

: 1262856-23-4
5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: (5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-yl)-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 0.75h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 124004-75-7
α,α,α-trifluoro-2-fluoroacetophenone

: 1262856-23-4
5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 12 steps

1: toluene; hexane

2: tetrahydrofuran

3: hydrogenchloride; sodium hydrogencarbonate; sodium tetrahydroborate; O₃ / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; oxygen

4: potassium carbonate; pyridine; DIPEA / hydrogenchloride; dichloromethane; 1,4-dioxane; methanol

5: potassium tert-butylate / ethyl acetate; tert-butyl alcohol; tetrahydrofuran

6: tetrahydrofuran

7: potassium carbonate / ammonia; methanol

8: potassium nitrate / sulfuric acid

9: DIPEA / dichloromethane; tetrahydrofuran

10: Pd on charcoal / ethanol; tetrahydrofuran

11: 1,2-dichloro-ethane; DIPEA / N,N-dimethyl-formamide

12: hydrogenchloride; trifluoroacetic acid / dichloromethane; ethyl acetate; diethyl ether; tetrahydrofuran

With pyridine; hydrogenchloride; sodium tetrahydroborate; O₃; DIPEA; potassium tert-butylate; sodium hydrogencarbonate; potassium carbonate; potassium nitrate; 1,2-dichloro-ethane; trifluoroacetic acid; Pd on charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; diethyl ether; ethanol; hexane; dichloromethane; sulfuric acid; ammonia; oxygen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1262860-12-7
[1-(2-Fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-carbamic acid tert-butyl ester

: 1262856-23-4
5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate; pyridine; DIPEA / hydrogenchloride; dichloromethane; 1,4-dioxane; methanol

2: potassium tert-butylate / ethyl acetate; tert-butyl alcohol; tetrahydrofuran

3: tetrahydrofuran

4: potassium carbonate / ammonia; methanol

5: potassium nitrate / sulfuric acid

6: DIPEA / dichloromethane; tetrahydrofuran

7: Pd on charcoal / ethanol; tetrahydrofuran

8: 1,2-dichloro-ethane; DIPEA / N,N-dimethyl-formamide

9: hydrogenchloride; trifluoroacetic acid / dichloromethane; ethyl acetate; diethyl ether; tetrahydrofuran

With pyridine; hydrogenchloride; DIPEA; potassium tert-butylate; potassium carbonate; potassium nitrate; 1,2-dichloro-ethane; trifluoroacetic acid; Pd on charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; diethyl ether; ethanol; dichloromethane; sulfuric acid; ammonia; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;