[4-(4-Fluorophenyl)phenyl]methanol

Base Information

• Chemical Name: [4-(4-Fluorophenyl)phenyl]methanol
• CAS No.: 147497-56-1
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.228
• Hs Code.: 2905190098
• DSSTox Substance ID: DTXSID40362755
• Wikidata: Q82146135
• Mol file: 147497-56-1.mol

Synonyms:147497-56-1;[4-(4-fluorophenyl)phenyl]methanol;4-(4-fluorophenyl)benzyl alcohol;(4'-Fluoro-1,1'-biphenyl-4-yl)methanol;(4'-FLUORO-[1,1'-BIPHENYL]-4-YL)METHANOL;(4'-Fluoro[1,1'-biphenyl]-4-yl)methanol;(4/'-FLUOROBIPHENYL-4-YL)-METHANOL;[1,1'-Biphenyl]-4-methanol, 4'-fluoro-;{4'-fluoro-[1,1'-biphenyl]-4-yl}methanol;[1,1'-Biphenyl]-4-methanol,4'-fluoro-;4'-Fluoro-[1,1'-biphenyl]-4-methanol;4'-fluoro-4-biphenylylmethanol;SCHEMBL4412749;4'-fluoro-4-biphenylyl-methanol;DTXSID40362755;(4'-fluorobiphenyl-4-yl)methanol;MFCD01862513;AKOS002683538;AS-8752;BB 0224036;CS-0206665

Chemical Property of [4-(4-Fluorophenyl)phenyl]methanol

Chemical Property:

• Boiling Point: 337.3 °C at 760 mmHg
• Flash Point: 190.4 °C
• PSA: 20.23000
• Density: 1.17 g/cm³
• LogP: 2.98500
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 202.079393132
• Heavy Atom Count: 15
• Complexity: 179

Purity/Quality:

99%, ^*data from raw suppliers

4-(4-Fluorophenyl)benzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1CO)C2=CC=C(C=C2)F

Technology Process of [4-(4-Fluorophenyl)phenyl]methanol

There total 4 articles about [4-(4-Fluorophenyl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromobenzenemethanol (873-75-6) + 4-fluoroboronic acid (1765-93-1) → (4'-Fluoro-biphenyl-4-yl)-methanol (147497-56-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; Inert atmosphere; Reflux;

Reference yield: 91.0%

4'-fluoro-biphenyl-4-carboxylic acid (5731-10-2) → (4'-Fluoro-biphenyl-4-yl)-methanol (147497-56-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm501455s

Reference yield:

methyl 4'-fluoro-[1,1'-biphenyl]-4-carboxylate (80254-87-1) → (4'-Fluoro-biphenyl-4-yl)-methanol (147497-56-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran;

upstream raw materials:

methyl 4'-fluoro-[1,1'-biphenyl]-4-carboxylate

4'-fluoro-biphenyl-4-carboxylic acid

4-bromobenzenemethanol

4-fluoroboronic acid

Downstream raw materials:

4-(bromomethyl)-4′-fluoro-1,1′-biphenyl

4-Chloromethyl-4'-fluoro-biphenyl