(4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Base Information

Chemical Name:(4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene
CAS No.:127951-22-8
Molecular Formula:C₂₃H₂₇NO₇
Molecular Weight:429.47
Hs Code.:

Synonyms:(4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

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Chemical Property of (4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

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Technology Process of (4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

There total 31 articles about (4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 127951-28-4
(4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

: 127951-22-8
(4aS,6R,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: With aluminium hydride; In tetrahydrofuran; at -30 - -10 ℃; for 2h;
DOI:10.1016/S0040-4039(01)80682-1

Reference yield:

: 58095-76-4
(E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

: 127951-22-8
(4aR,6R,11bR)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: Multi-step reaction with 5 steps

1: aqueous pyridinium bromide / dioxane / 72 h

2: p-toluenesulfonic acid / CH₂Cl₂ / 24 h / 23 °C

3: 1.) BuLi / 1.) THF, -75 deg C, 10 min

4: sodium hydride / dimethylformamide / 0 °C

5: sodium napthalenide/dimethoxyethane / tetrahydrofuran / 0.17 h / -75 °C

With n-butyllithium; 1,2-dimethoxyethane; Pyridine hydrobromide; sodium hydride; sodium naphthalenide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95275-4

Reference yield:

: 123474-70-4
2-Bromo-1-(6-bromo-benzo[1,3]dioxol-5-yl)-propane-1,3-diol

: 127951-22-8
(4aR,6R,11bR)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / CH₂Cl₂ / 24 h / 23 °C

2: 1.) BuLi / 1.) THF, -75 deg C, 10 min

3: sodium hydride / dimethylformamide / 0 °C

4: sodium napthalenide/dimethoxyethane / tetrahydrofuran / 0.17 h / -75 °C

With n-butyllithium; 1,2-dimethoxyethane; sodium hydride; sodium naphthalenide; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95275-4