(4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Base Information

Chemical Name:(4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene
CAS No.:127951-28-4
Molecular Formula:C₂₃H₂₅NO₇
Molecular Weight:427.454
Hs Code.:

Synonyms:(4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

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Chemical Property of (4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

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Technology Process of (4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

There total 14 articles about (4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 127951-20-6,127951-27-3
N-((4R,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-dimethyl-[1,3]dioxan-5-yl)-3,4,5-trimethoxy-benzamide

: 127951-28-4
(4aS,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: With PPSE(trimethylsylilpolyphosphate) in CH₂Cl₂; In pyridine; for 18h; Heating;
DOI:10.1016/S0040-4039(01)80682-1

Reference yield: 40.0%

: 127951-20-6,127951-27-3
N-((4R,5S)-4-Benzo[1,3]dioxol-5-yl-2,2-dimethyl-[1,3]dioxan-5-yl)-3,4,5-trimethoxy-benzamide

: 127951-28-4
(4aR,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: With phosphorus pentoxide; In pyridine; at 110 ℃; for 2.5h;
DOI:10.1016/S0040-4039(01)80682-1

Reference yield:

: 25054-53-9
3,4-(methylenedioxy)benzoyl chloride

: 127951-28-4
(4aR,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,11b-dihydro-4H-1,3,8,10-tetraoxa-5-aza-cyclopenta[b]phenanthrene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / -70 deg C, HMPA

2: 91 percent / LiBH₄ / 1,2-dimethoxy-ethane / 12 h / Ambient temperature

3: 93 percent / p-TSA / acetone / 18 h / Ambient temperature

4: 40 percent / P₂O₅ / pyridine / 2.5 h / 110 °C

With lithium borohydride; phosphorus pentoxide; toluene-4-sulfonic acid; lithium diisopropyl amide; In pyridine; 1,2-dimethoxyethane; acetone;
DOI:10.1016/S0040-4039(01)80682-1