(S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid

Base Information

• Chemical Name: (S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid
• CAS No.: 1107616-74-9
• Molecular Formula: C₉H₈F₂O₃
• Molecular Weight: 202.158
• Mol file: 1107616-74-9.mol

Synonyms:(S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid

Chemical Property of (S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid

Chemical Property:

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Technology Process of (S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid

There total 1 articles about (S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(2,4-difluorophenyl)-3-oxopropanenitrile (71682-95-6) → (S)-3-(2',4'-difluorophenyl)-3-hydroxypropanoic acid (1107616-74-9)

Guidance literature:

3-(2,4-difluorophenyl)-3-oxopropanenitrile; With D-glucose; D-glucose dehydrogenase; alcohol dehydrogenase YMR₂₂₆c from Saccharomyces cerevisiae; NADPH; In dimethyl sulfoxide; at 20 ℃; for 24h; pH=7.0; potassium phosphate buffer; Enzymatic reaction;

With nitrilase from Bradyrhizobium japonicum strain USDA₁₁₀; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=7.2; optical yield given as %ee; enantioselective reaction; potassium phosphate buffer; Enzymatic reaction;

DOI:10.1021/jo802495f

upstream raw materials:

3-(2,4-difluorophenyl)-3-oxopropanenitrile

Refernces