71682-95-6Relevant articles and documents
Phase transfer catalyst in grindstone synthesis of 3-oxopropanenitrile: One pot synthesis of polysubstituted amino thiophenes
Patil, Shivaraj P.,Kanawade, Shrikant B.,Shinde, Madhukar P.,Toche, Raghunath B.
, p. 33 - 36 (2013/09/24)
The chemoselective SN2 reaction of ω-bromoacetophenone with sodium cyanide or potassium cyanide in DMF-water or in biphasic solvent toluene-water using tetrabutylammonium bromide (TBAB) as phase-transfer catalyst, performed by grinding, furnished 3-oxopropanenitriles 2 as the sole product in 70-80% yield, while in ethanolwater, mixture of compound 2 and oxirane 3 were obtained. The obtained 3-oxopropanenitriles 2 were used for one pot synthesis of 2-amino-3-carbonitrile thiophenes.
Potential antiarthritic agents. II. Benzoylacetonitriles and β-aminocinnamonitriles
Ridge,Hanifin,Harten,Johnson,Menschik,Nicolau,Sloboda,Watts
, p. 1385 - 1389 (2007/10/09)
Benzoylacetonitrile and β-aminocinnamonitrile are shown to possess potent intiinflammatory activity in the rat adjuvant arthritis model. In a series of phenyl-substituted analogues, only o-, m-, and p-fluorobenzoylacetonitrile and m- and p-fluoro-β-aminocinnamonitrile retained activity. Additionally, β-amino-2- and β-amino-3-thiopheneacrylonitrile and β-oxo-2- and β-oxo-3-thiophenepropionitrile exhibited similar activity. These agents are not believed to be acting via prostaglandin synthetase inhibition. The metabolic profile of benzoylacetonitrile is also described.
