[1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester

Base Information

• Chemical Name: [1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester
• CAS No.: 543744-98-5
• Molecular Formula: C₁₇H₂₄N₂O₃
• Molecular Weight: 304.389
• Mol file: 543744-98-5.mol

Synonyms:[1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester

Chemical Property of [1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester

There total 1 articles about [1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-Fluorobenzaldehyde (446-52-6) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → [1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester (543744-98-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 85 ℃;

DOI:10.1016/j.bmcl.2006.11.071

Reference yield: 58.0%

[1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester (543744-98-5) → [1-(2-Methylaminomethylphenyl)piperidin-4-yl]-carbamic acid t-butyl ester (543744-99-6)

Guidance literature:

With sodium hydroxide; methylamine hydrochloride; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane;

Reference yield:

[1-(2-Formylphenyl)-piperidin-4-yl]carbamic acid t-butyl ester (543744-98-5) → 1-(2-methylaminomethyl-phenyl)-piperidin-4-ylamine

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH(OAc)3 / 1,2-dichloro-ethane

2: HCl / dioxane

With hydrogenchloride; sodium tris(acetoxy)borohydride; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2006.11.071

upstream raw materials:

2-Fluorobenzaldehyde

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

[1-(2-Methylaminomethylphenyl)piperidin-4-yl]-carbamic acid t-butyl ester

1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-ylamine

2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperidin-4-yl]-amide