2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol

Base Information

• Chemical Name: 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol
• CAS No.: 78077-41-5
• Molecular Formula: C₂₂H₂₉BrO₃
• Molecular Weight: 421.374
• Mol file: 78077-41-5.mol

Synonyms:2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol

Chemical Property of 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol

There total 3 articles about 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(3-bromo-5-t-butyl-2-hydroxybenzyl)-4-t-butylphenol (78077-40-4) → 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol (78077-41-5)

Guidance literature:

With sodium hydroxide; at 50 ℃; for 16h;

DOI:10.1021/ja00403a028

Reference yield:

para-tert-butylphenol (98-54-4) → 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol (78077-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / aq. HCl / 20 h / 110 °C

2: 77 percent / aq. NaOH / 16 h / 50 °C

With hydrogenchloride; sodium hydroxide;

DOI:10.1021/ja00403a028

Reference yield:

2-bromo-4-tert-butyl-6-(hydroxymethyl)phenol (2599-63-5) → 2-(3-bromo-5-tert-butylsalicyl)-5-tert-butyl-2-hydroxybenzyl alcohol (78077-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / aq. HCl / 20 h / 110 °C

2: 77 percent / aq. NaOH / 16 h / 50 °C

With hydrogenchloride; sodium hydroxide;

DOI:10.1021/ja00403a028

upstream raw materials:

formaldehyd

2-(3-bromo-5-t-butyl-2-hydroxybenzyl)-4-t-butylphenol

para-tert-butylphenol

2-bromo-4-tert-butyl-6-(hydroxymethyl)phenol

Downstream raw materials:

2-<3-(3-bromo-5-tert-butylsalicyl)-5-tert-butylsalicyl>-4-tert-butylphenol

3-<3-<3-(3-bromo-5-tert-butylsalicyl)-5-tert-butylsalicyl>-5-tert-butylsalicyl>-5-tert-butyl-2-hydroxybenzyl alcohol

2-<3-<3-(3-bromo-5-tert-butylsalicyl)-5-tert-butylsalicyl>-5-tert-butylsalicyl>-4-tert-butylphenol

3-<3-(3-bromo-5-tert-butylsalicyl)-5-tert-butylsalicyl>-5-tert-butyl-2-hydroxybenzyl alcohol