3-Bromo-5-methylpyridin-4-amine

Base Information

• Chemical Name: 3-Bromo-5-methylpyridin-4-amine
• CAS No.: 97944-43-9
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• European Community (EC) Number: 845-759-6
• DSSTox Substance ID: DTXSID90540243
• Wikidata: Q82416165
• Mol file: 97944-43-9.mol

Synonyms:3-Bromo-5-methylpyridin-4-amine;97944-43-9;4-Amino-3-bromo-5-methylpyridine;4-Amino-5-bromo-3-methylpyridine;3-Bromo-5-methyl-pyridin-4-ylamine;MFCD07437841;4-Pyridinamine, 3-bromo-5-methyl-;4-Amino-5-bromo-3-picoline;4-Pyridinamine,3-bromo-5-methyl-;SCHEMBL14206718;SCHEMBL23234761;AMY7928;DTXSID90540243;GUAFGBUKLIFASX-UHFFFAOYSA-N;AKOS006284117;GS-5725;SB40341;AC-33416;SY066924;CS-0042800;EN300-105074;Z1198173286;2-(2-CYCLOPENTYLETHYL)-6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXYLICACID

Chemical Property of 3-Bromo-5-methylpyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.00212mmHg at 25°C
• Melting Point: 115.0 °C
• Refractive Index: 1.617
• Boiling Point: 290.017 °C at 760 mmHg
• PKA: 7.34±0.24(Predicted)
• Flash Point: 129.198 °C
• PSA: 38.91000
• Density: 1.593 g/cm³
• LogP: 2.31590
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 185.97926
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98% ^*data from raw suppliers

3-Bromo-5-methylpyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=CC(=C1N)Br

Technology Process of 3-Bromo-5-methylpyridin-4-amine

There total 1 articles about 3-Bromo-5-methylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-amino-3-methylpyridine (1990-90-5,953018-16-1) → 4-amino-5-bromo-3-methylpyridine (97944-43-9)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; In water; at 70 ℃; for 2h;

Reference yield: 13.0%

copper(I) cyanide (544-92-3) + 4-amino-5-bromo-3-methylpyridine (97944-43-9) → 4-amino-3-cyano-5-methylpyridine (183428-93-5)

Guidance literature:

In N,N-dimethyl-formamide; for 20h; Heating;

DOI:10.1002/prac.199633801126

Reference yield:

4-amino-5-bromo-3-methylpyridine (97944-43-9) → C12H7Cl2N3 (845752-01-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / toluene / 9 h / 110 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 24 h / 85 °C

3: potassium acetate; acetic anhydride / benzene / 5.5 h / 90 °C

4: methanol; lithium hydroxide / 2 h / 20 °C / Heating / reflux

With methanol; lithium hydroxide; potassium acetate; acetic anhydride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; toluene; benzene;

upstream raw materials:

4-amino-3-methylpyridine

Downstream raw materials:

4-amino-3-cyano-5-methylpyridine

C₁₂H₇Cl₂N₃

C₁₄H₁₂Cl₂N₂O

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