4-AMINOCYCLOHEXANONE HCL

Base Information

• Chemical Name: 4-AMINOCYCLOHEXANONE HCL
• CAS No.: 675112-40-0
• Molecular Formula: C₆H₁₁NO*ClH
• Molecular Weight: 149.62
• Hs Code.: 2922399090
• Mol file: 675112-40-0.mol

Synonyms:Cyclohexanone,4-amino-, hydrochloride (9CI); 4-Aminocyclohexanone hydrochloride

Chemical Property of 4-AMINOCYCLOHEXANONE HCL

Chemical Property:

• Melting Point: 205 °C(dec.)
• PSA: 43.09000
• LogP: 1.95910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Aminocyclohexanone Hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINOCYCLOHEXANONE HCL

There total 5 articles about 4-AMINOCYCLOHEXANONE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(4-oxocyclohexyl)acetamide (27514-08-5) → 4-aminocyclohexan-1-one hydrochloride (675112-40-0)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1016/j.bmcl.2004.03.085

Reference yield: 92.0%

N-(tert-butoxycarbonyl)-4-aminocyclohexanone (179321-49-4) → 4-aminocyclohexan-1-one hydrochloride (675112-40-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

4-oxocyclohexane-1-carboxamide (204136-88-9) → 4-aminocyclohexan-1-one hydrochloride (675112-40-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 5 - 20 ℃; for 6h;

upstream raw materials:

N-(4-oxocyclohexyl)acetamide

N-(tert-butoxycarbonyl)-4-aminocyclohexanone

4-oxocyclohexane-1-carboxamide

4,4-dimethoxycyclohexanecarboxamide

Downstream raw materials:

6-(benzo[d]thiazol-6-ylamino)-4-(isopropylamino)-N-(4-oxocyclohexyl)nicotinamide

Refernces

• 1、 -. "(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS". Page/Page column 146. . Retrieved 2013/05/09.
• 2、 Krajnc, Andreja,Peterlin-Masic, Lucija,Ilas, Janez,Prezelj, Andrej,Stegnar, Mojca,Kikelj, Danijel. "Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties.". . p. 3251 - 3256. Retrieved 2007/10/03.