4-bromo-1-methy-2-nitro-1H-imidazole

Base Information

• Chemical Name: 4-bromo-1-methy-2-nitro-1H-imidazole
• CAS No.: 121816-79-3
• Molecular Formula: C4H4 Br N3 O2
• Molecular Weight: 205.9975
• Hs Code.: 2933290090
• Mol file: 121816-79-3.mol

Synonyms:4-Bromo-1-methyl-2-nitroimidazole

Chemical Property of 4-bromo-1-methy-2-nitro-1H-imidazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 370.719°C at 760 mmHg
• Flash Point: 178.005°C
• PSA: 63.64000
• Density: 2.043g/cm³
• LogP: 1.61400
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-1-methyl-2-nitro-1H-imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-1-methy-2-nitro-1H-imidazole

There total 4 articles about 4-bromo-1-methy-2-nitro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-methyl-2-nitroimidazole (1671-82-5,176738-19-5) → 4-bromo-1-methyl-2-nitroimidazole (121816-79-3)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield: 37.0%

4-bromo-2-nitro-1H-imidazole (121816-84-0) + dimethyl sulfate (77-78-1) → 4-bromo-1-methyl-2-nitroimidazole (121816-79-3) + 4,5'-Dibromo-3'-methyl-2'-nitro-1H,3'H-[2,4']biimidazolyl (121816-86-2)

Guidance literature:

With potassium carbonate; In acetone; for 0.5h; Yields of byproduct given; Heating;

Reference yield: 15.0%

1-methyl-2-nitroimidazole (1671-82-5,176738-19-5) → 4-bromo-1-methyl-2-nitroimidazole (121816-79-3) + 5-bromo-1-methyl-2-nitroimidazole (151597-78-3)

Guidance literature:

With bromine; In 1,4-dioxane; for 144h; Ambient temperature;

upstream raw materials:

1-methyl-2-nitroimidazole

4-bromo-2-nitro-1H-imidazole

dimethyl sulfate

Downstream raw materials:

4-bromo-1-methyl-1H-imidazol-2-amine hydrochloride

Refernces

• 1、 Farah, Salim F.,McClelland, Robert A.. "Preparation and reactions of bromo-2-nitro- and bromo-2-aminoimidazoles". . p. 427 - 432. Retrieved 2007/10/02.