N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

Base Information

Chemical Name:N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide
CAS No.:1569294-13-8
Molecular Formula:C₂₇H₃₄IN₅O₃
Molecular Weight:603.503
Hs Code.:

Synonyms:N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

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Chemical Property of N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

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Technology Process of N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

There total 5 articles about N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1410578-64-1
ethyl 6-(2-iodophenoxy)hexanoic acid

: 1569294-13-8
N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 18 h / 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux

3: dmap / 18 h / 45 °C / Inert atmosphere

With dmap; thionyl chloride; lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ml400468x

Reference yield:

: 1236230-64-0
6-(2-iodophenoxy)hexanoic acid

: 1569294-13-8
N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux

2: dmap / 18 h / 45 °C / Inert atmosphere

With dmap; thionyl chloride; In dichloromethane;
DOI:10.1021/ml400468x

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 1569294-13-8
N-(2-(N,N-diethylamino)ethyl)-6-(6-(2-iodophenoxy)hexanamido)quinoxaline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 80 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 18 h / 20 °C / Inert atmosphere

3: thionyl chloride / dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux

4: dmap / 18 h / 45 °C / Inert atmosphere

With dmap; thionyl chloride; lithium hydroxide monohydrate; water; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml400468x