2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Base Information

Chemical Name:2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline
CAS No.:1567334-91-1
Molecular Formula:C₂₆H₃₂ClN₃O
Molecular Weight:438.013
Hs Code.:

Synonyms:2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Suppliers and Price of 2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

There total 8 articles about 2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1567334-93-3
2-(5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl)aniline

: 75-07-0,9002-91-9
acetaldehyde

: 1567334-91-1
2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Guidance literature:: 2-(5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl)aniline; acetaldehyde; In tetrahydrofuran; for 0.25h;

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; for 72h;

Reference yield:

: 1567334-90-0
5-(4-chlorophenyl)-1-(2-nitrophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole

: 1567334-91-1
2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; iron / ethanol / 1 h / 90 °C

2.1: tetrahydrofuran / 0.25 h

2.2: 72 h

With iron; acetic acid; In tetrahydrofuran; ethanol;

Reference yield:

: 1567335-31-2
benzotriazol-1-yl-(2,2,6,6-tetramethyltetrahydropyran-4-yl)methanone

: 1567334-91-1
2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl]-N-ethylaniline

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; magnesium dibromide / dichloromethane

2: methanol

3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; magnesium dibromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene; 4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2018.10.007