methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

Base Information

Chemical Name:methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate
CAS No.:1012058-01-3
Molecular Formula:C₂₁H₁₇ClFN₃O₃
Molecular Weight:413.836
Hs Code.:

Synonyms:methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

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Chemical Property of methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

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Technology Process of methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

There total 1 articles about methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1012920-25-0
C₁₅H₁₀ClFIN₃O

: 21565-82-2
methyl pent-4-ynoate

: 1012058-01-3
methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

Guidance literature:: With copper(l) iodide; triethylamine; triphenylphosphine; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield: 94.0%

: 1012058-01-3
methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

: 1012058-03-5
C₂₁H₂₁ClFN₃O₃

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield: 74.0%

: 1012058-01-3
methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate

: C₂₀H₁₆ClFN₄O₃

Guidance literature:: methyl 5-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)pent-4-ynoate; With hydroxylamine; In methanol; at 20 ℃; for 0.5h;

With acetic acid; In methanol; pH=7;