N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine

Base Information

• Chemical Name: N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine
• CAS No.: 757956-22-2
• Molecular Formula: C₁₃H₁₈N₂O₄S
• Molecular Weight: 298.363
• Mol file: 757956-22-2.mol

Synonyms:N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine

Chemical Property of N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine

There total 1 articles about N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid hydrazide (1576-35-8) + 2,3-isopropylidene-glyceraldehyde (15186-48-8) → N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine (757956-22-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1021/jo0499118

Reference yield: 41.0%

N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine (757956-22-2) + phenyl isopropyl sulfone (4238-09-9) → (4R)-2,2-dimethyl-4-(2-methylprop-1-enyl)-1,3-dioxolane + 2,3-dimethyl-3-(phenylsulfonyl)butan-2-ol

Guidance literature:

phenyl isopropyl sulfone; With isopropylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 1.5h;

N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jo0499118

Reference yield: 24.0%

N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine (757956-22-2) + cyclohexyl phenyl sulfone (6947-57-5) → (4R)-4-(cyclohexylidenemethyl)-2,2-dimethyl-1,3-dioxolane + 2-[1-(phenylsulfonyl)cyclohexyl]propan-2-ol

Guidance literature:

cyclohexyl phenyl sulfone; With isopropylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 3h;

N'-{(1E)-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-(4-methylbenzenesulfonyl)hydrazine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jo0499118

upstream raw materials:

toluene-4-sulfonic acid hydrazide

2,3-isopropylidene-glyceraldehyde

Downstream raw materials:

(4R)-2,2-dimethyl-4-[(1Z)-4-phenylbut-1-enyl]-1,3-dioxolane

(4R)-2,2-dimethyl-4-[(1E)-4-phenylbut-1-enyl]-1,3-dioxolane