4238-09-9

Basic information

• Product Name: ISOPROPYLPHENYL SULFONE
• Synonyms: ISOPROPYLPHENYL SULFONE;2-(Phenylsulfonyl)propane;Phenyl isopropyl sulfone;(propane-2-sulfonyl)benzene
• CAS NO: 4238-09-9
• Molecular Formula: C₉H₁₂O₂S
• Molecular Weight: 302.43108
• Mol File: 4238-09-9.mol
• Article Data: 51

Chemical Properties

• Boiling Point: 317.3°Cat760mmHg
• Flash Point: 172.1°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 0.000723mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: ISOPROPYLPHENYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOPROPYLPHENYL SULFONE(4238-09-9)
• EPA Substance Registry System: ISOPROPYLPHENYL SULFONE(4238-09-9)

Safety Data

• Hazardous Substances Data: 4238-09-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12O2S/c1-8(2)12(10,11)9-6-4-3-5-7-9/h3-8H,1-2H3

Upstream product

• 75-30-9 2-iodo-propane 
• 873-55-2 sodium benzenesulfonate 
• 75-26-3 isopropyl bromide 
• 4170-69-8 isopropyl phenyl sulfoxide 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 1068-55-9 isopropylmagnesium chloride 
• 108-98-5 thiophenol 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 5535-48-8 PVS 
• 807329-97-1 TurboGrignard 
• 38111-45-4 iso-propylzinc chloride 
• 3019-20-3 isopropylthiobenzene 

Downstream Products

• 68453-81-6 2-Phenylsulfonyl-2-iodpropan 
• 133827-98-2 3-Benzenesulfonyl-3-methyl-1-trimethylsilanyl-butan-1-ol 
• 556-82-1 3-methyl-2-buten-1-ol 
• 5205-11-8 3-methyl-2-butenyl benzoate 
• 133827-97-1 3-benzenesulfonyl-3-methyl-1-trimethylsilyl-butan-1-ol benzoate 
• 91787-39-2 trimethyl<1-(phenylsulphonyl)ethyl>silane 
• 130837-17-1 <2-<<1-methyl-1-(trimethylsilyl)ethyl>sulphonyl>phenyl>trimethylsilane 
• 118335-07-2 <2-<(1,1-dimethylethyl)sulphonyl>phenyl>trimethylsilane 
• 1053621-95-6 2,4-Bis-benzenesulfonyl-2,4-dimethyl-pentan-3-ol 
• 563-79-1 2,3-Dimethyl-2-butene 
• 4170-72-3 tert-butyl-phenyl sulfone 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 1609735-17-2 5-chloro-4-(2-(phenylsulfonyl)propan-2-yl)pyrimidine 
• 1609735-16-1 4-(2-(phenylsulfonyl)propan-2-yl)quinazoline 

Relevant articles and documents

Alkylation of Nitropyridines via Vicarious Nucleophilic Substitution

Electrophilic nitropyridines react with sulfonyl-stabilized carbanions to give products of C-H alkylation via vicarious nucleophilic substitution. The process consists of formation of the Meisenheimer-type adduct followed by base-induced β-elimination of the sulfinic acid (e.g., PhSO2H). Mechanistic studies reveal that in the latter step alkyl substituent and adjacent nitro group tend to planarize for effective stabilization of benzyl anion, and thus, adduct of hindered isopropyl carbanion remains stable toward elimination for steric reasons.

Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent. TBSOMS-Na, easily prepared from the commercial reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles. The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a separate unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.

Calcium tungstate: A convenient recoverable catalyst for hydrogen peroxide oxidation

Calcium tungstate was found to be an excellent catalyst for large scale "green" oxidations of organic substrates (amines, alkenes, alcohols, sulfides) with hydrogen peroxide. It displays the unusual dual characteristics of producing a soluble pertungstate species, allowing for homogeneous reaction conditions, but then precipitating, unchanged, at the end of the oxidation. These qualities allow for easy catalyst recovery and minimal waste stream generation for large scale application.