(R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one

Base Information

• Chemical Name: (R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one
• CAS No.: 1252018-28-2
• Molecular Formula: C₁₄H₁₅ClN₂O₄
• Molecular Weight: 310.737
• Mol file: 1252018-28-2.mol

Synonyms:4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one

Chemical Property of (R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one

Chemical Property:

• Melting Point: 148-149.7 °C
• Boiling Point: 582.2±45.0 °C(Predicted)
• PKA: 0.99±0.20(Predicted)
• Density: 1.388±0.06 g/cm3(Predicted)

Purity/Quality:

>97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one

There total 7 articles about (R)-4-(4-(5-(chloroMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-(-)-epichlorohydrin (51594-55-9,24969-06-0,13403-37-7) + 4-(4-isocyanatophenyl)morpholin-3-one (1325210-64-7) → 4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (1252018-28-2)

Guidance literature:

With MgI₂*etherate; In tetrahydrofuran; at 20 - 80 ℃; Inert atmosphere;

DOI:10.3184/174751911X13098778358582

Reference yield: 74.8%

4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one (1252018-10-2) + 1,1'-carbonyldiimidazole (530-62-1) → 4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (1252018-28-2)

Guidance literature:

In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one (1252018-10-2) → 4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (1252018-28-2)

Guidance literature:

In chloroform; at 30 ℃; for 20h;

upstream raw materials:

(R)-(-)-epichlorohydrin

4-(4-isocyanatophenyl)morpholin-3-one

4-phenylmorpholin-3-one

2-Anilinoethanol

Downstream raw materials:

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Rivaroxaban

4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione