1325210-64-7

Basic information

• Product Name: 4-(4-Isocyanatophenyl)Morpholin-3-one (4-(4-isocyanatophenyl)-3-Morpholinone)
• Synonyms: 4-(4-Isocyanatophenyl)Morpholin-3-one (4-(4-isocyanatophenyl)-3-Morpholinone);4-(4-isocyanatophenyl)-3-Morpholinone;4-(3-Oxomorpholino)phenyl isocyanate;4-(4-Isocyanatophenyl)morpholin-3-one
• CAS NO: 1325210-64-7
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.2087
• Mol File: 1325210-64-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-Isocyanatophenyl)Morpholin-3-one (4-(4-isocyanatophenyl)-3-Morpholinone)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Isocyanatophenyl)Morpholin-3-one (4-(4-isocyanatophenyl)-3-Morpholinone)(1325210-64-7)
• EPA Substance Registry System: 4-(4-Isocyanatophenyl)Morpholin-3-one (4-(4-isocyanatophenyl)-3-Morpholinone)(1325210-64-7)

Safety Data

• Hazardous Substances Data: 1325210-64-7(Hazardous Substances Data)

Usage

General Description

4-(4-Isocyanatophenyl)Morpholin-3-one, also known as 4-(4-isocyanatophenyl)-3-Morpholinone, is a chemical compound with the molecular formula C11H11NO3. It is an isocyanate derivative that contains a morpholine ring, and it is commonly used in the production of polyurethane foams and elastomers. This chemical is a highly reactive, colorless solid with a distinctive odor. It is also classified as a hazardous material due to its toxicity and potential to cause skin and respiratory irritation. Additionally, 4-(4-Isocyanatophenyl)Morpholin-3-one is used in the manufacturing of adhesives, coatings, and sealants, and it is important to handle this substance with the proper safety precautions and equipment.

Upstream product

• 122-98-5 2-Anilinoethanol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 
• 29518-11-4 4-phenylmorpholin-3-one 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 366789-02-8 Rivaroxaban 
• 721401-53-2 5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide 
• 446292-10-0 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one 
• 1349248-79-8 4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 
• 1252018-28-2 4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1414932-72-1 4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 
• 446292-08-6 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 
• 1424942-78-8 4-{4-[(5S)-5-(N-benzylaminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morphoIin-3-one 
• 1372665-04-7 4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1416129-92-4 tert-butyl {(5S)-3-[4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 

Relevant articles and documents

METHOD FOR PREPARING RIVAROXABAN INTERMEDIATE

A method for preparing a Rivaroxaban intermediate I is presented, including the following step: in a non-protonic solvent, under the effect of lewis acid, performing cyclization reaction on 4-(4-phenyl isocyanate)morpholine-3-ketone (II) and (S)-epoxy compound (III), the reaction temperature ranging from 20° C. to 60° C., where R is amino replaced by amino protecting group. The preparation method of the present invention has a mild condition, a simple process, a low cost, and high efficiency; the product is easy to purify and the method is applicable to industrial production.

PROCESSES FOR PREPARING RIVAROXABAN

Processes and intermediates for preparing rivaroxaban, and analogs and derivatives thereof, and pharmaceutically acceptable salts of each of the foregoing, are described herein.

Method for the preparation of rivaroxaban

The present invention relates to the use of a compound having the formula (II) for the preparation of a compound having the formula (V). Methods of preparing the compound having the formula (V) using the compound having the formula (II) are also described. Individual reaction steps as well as intermediates are additionally claimed.