5-bromo-2-chloro-N-[2-(ethylamino)pyridin-3-yl]pyridine-3-carboxamide

Base Information

• Chemical Name: 5-bromo-2-chloro-N-[2-(ethylamino)pyridin-3-yl]pyridine-3-carboxamide
• CAS No.: 380378-90-5
• Molecular Formula: C₁₃H₁₂BrClN₄O
• Molecular Weight: 355.621
• DSSTox Substance ID: DTXSID30475868
• Wikidata: Q82306684
• Mol file: 380378-90-5.mol

Synonyms:380378-90-5;5-bromo-2-chloro-N-[2-(ethylamino)pyridin-3-yl]pyridine-3-carboxamide;SCHEMBL5746260;DTXSID30475868;FGAWMWXLCMDXFM-UHFFFAOYSA-N;5-Bromo-2-chloro-N-[2-(ethylamino)-3-pyridinyl]nicotinamide;FT-0747871;2-chloro-n-{2-(ethylamino)-3-pyridinyl}-5-bromo-3-pyridinecarboxamide

Chemical Property of 5-bromo-2-chloro-N-[2-(ethylamino)pyridin-3-yl]pyridine-3-carboxamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.678
• Boiling Point: 428.699 °C at 760 mmHg
• Flash Point: 213.07 °C
• PSA: 66.91000
• Density: 1.621g/cm³
• LogP: 3.72260
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 353.98830
• Heavy Atom Count: 20
• Complexity: 334

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCNC1=C(C=CC=N1)NC(=O)C2=C(N=CC(=C2)Br)Cl

Technology Process of 5-bromo-2-chloro-N-[2-(ethylamino)pyridin-3-yl]pyridine-3-carboxamide

There total 2 articles about 5-bromo-2-chloro-N-[2-(ethylamino)pyridin-3-yl]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-amino-2-(ethylamino)pyridine (32282-06-7) + 5-bromo-2-chloro-pyridine-3-carbonyl chloride (78686-86-9) → [2-chloro-N-{2-(ethylamino)-3-pyridinyl}-5-bromo-3-] pyridinecarboxamide (380378-90-5)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; for 2.08333h;

Reference yield: 69.0%

3-amino-2-(ethylamino)pyridine (32282-06-7) + 5-bromo-2-hydroxynicotinic acid (104612-36-4) → [2-chloro-N-{2-(ethylamino)-3-pyridinyl}-5-bromo-3-] pyridinecarboxamide (380378-90-5)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield: 75.0%

[2-chloro-N-{2-(ethylamino)-3-pyridinyl}-5-bromo-3-] pyridinecarboxamide (380378-90-5) → 5,11-dihydro-11-ethyl-8-bromo-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (134698-42-3)

Guidance literature:

In pyridine; at 50 ℃; for 0.166667h;

upstream raw materials:

3-amino-2-(ethylamino)pyridine

5-bromo-2-chloro-pyridine-3-carbonyl chloride

5-bromo-2-hydroxynicotinic acid

Downstream raw materials:

5,11-dihydro-11-ethyl-8-bromo-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one