8-Bromo-11-ethyl-5,11-dihydro-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin-6-one

Base Information

Chemical Name:8-Bromo-11-ethyl-5,11-dihydro-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin-6-one
CAS No.:134698-42-3
Molecular Formula:C₁₃H₁₁BrN₄O
Molecular Weight:319.161
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90475869
Wikidata:Q82306685
Mol file:134698-42-3.mol

Synonyms:134698-42-3;8-BROMO-11-ETHYL-5,11-DIHYDRO-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE;13-bromo-2-ethyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one;WTTXVIRIPXYRIW-UHFFFAOYSA-N;SCHEMBL4031265;DTXSID90475869;FT-0751172;8-Bromo-11-ethyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one;8-Bromo-5,11-dihydro-11-ethyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Suppliers and Price of 8-Bromo-11-ethyl-5,11-dihydro-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 8-Bromo-11-ethyl-5,11-dihydro-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin-6-one

Chemical Property:

PSA：63.57000
LogP:2.61740
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:318.01162
Heavy Atom Count:19
Complexity:354

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C2=C(C=CC=N2)NC(=O)C3=C1N=CC(=C3)Br

Technology Process of 8-Bromo-11-ethyl-5,11-dihydro-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin-6-one

There total 7 articles about 8-Bromo-11-ethyl-5,11-dihydro-6H-dipyrido[3,2-B:2',3'-E][1,4]diazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 380378-90-5
[2-chloro-N-{2-(ethylamino)-3-pyridinyl}-5-bromo-3-] pyridinecarboxamide

: 134698-42-3
5,11-dihydro-11-ethyl-8-bromo-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Guidance literature:: In pyridine; at 50 ℃; for 0.166667h;

Reference yield: 75.0%

: 380378-90-5
[2-chloro-N-{2-(ethylamino)-3-pyridinyl}-5-bromo-3-] pyridinecarboxamide

NaHMDS (sodium hexamethyldisilazide): NaHMDS (sodium hexamethyldisilazide)

: 134698-42-3
5,11-dihydro-11-ethyl-8-bromo-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Guidance literature:: In tetrahydrofuran; pyridine; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield:

: 5-bromo-N-(2-chloropyridin-3-yl)-2-ethylaminonicotinamide

: 134698-42-3
5,11-dihydro-11-ethyl-8-bromo-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 50 - 55 ℃; for 4h; Inert atmosphere; Large scale;
DOI:10.1021/op8000756