4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole

Base Information

• Chemical Name: 4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole
• CAS No.: 1024029-99-9
• Molecular Formula: C₂₂H₂₉ClN₂O₆
• Molecular Weight: 452.935
• Mol file: 1024029-99-9.mol

Synonyms:4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole

Chemical Property of 4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole

Chemical Property:

Purity/Quality:

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Technology Process of 4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole

There total 1 articles about 4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C14H16BrClO2 + di-isopropyl azodicarboxylate (2446-83-5) → 4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole (1024029-99-9)

Guidance literature:

With dimethylsulfide; potassium carbonate; In water; acetonitrile; at 20 ℃; for 9h;

DOI:10.1021/ol800424v

Reference yield: 64.0%

4-tert-butoxycarbonyl-3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole (1024029-99-9) → 3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1024030-07-6)

Guidance literature:

With methanesulfonic acid; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1021/ol800424v

upstream raw materials:

di-isopropyl azodicarboxylate

Downstream raw materials:

3-(4-chlorophenyl)-1,2-bis(iso-propoxycarbonyl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid