2446-83-5 Usage
Product description
Isopropyl azodicarboxylate (Acronym DIAD; foaming agent DIPA) belongs to diisopropyl azo-hydroxy acid salt. At room temperature, it is an orange-red transparent oily liquid with special smell and is soluble in almost all organic solvents and plasticizers. It is also insoluble in water but soluble in common plasticizer. It can be well miscible with plastic with good thermal stability. Storage stability: the decomposition substance is colorless, non-toxic, non-pollution, non-blooming and odorless. In the range of 40~120 °C, it can obtain high gas evolution. It is also the liquid blowing agent of vinyl resin and can be used to make light-colored vinyl foam. It has a uniform pore structure, with different formulations and processing conditions obtaining the foam of either closed pore or open pore. It can also be used as pharmaceutical intermediates and organic synthesis reagents.
The above information is edited by the lookchem of Dai Xiongfeng.
Uses
Different sources of media describe the Uses of 2446-83-5 differently. You can refer to the following data:
1. It can be used as dye intermediates, pharmaceutical intermediates, organic synthesis reagents, and the foaming agent of the rubber plastics liquid.
Isopropyl azodicarboxylate can be used for the liquid foaming agent of vinyl resin. It can be used to make light-colored vinyl foam. It has a uniform pore structure with different formulations and processing conditions giving foam of either closed pore or open pore. It can also be used as pharmaceutical intermediates, and organic synthesis reagents.
2. Diisopropyl Azodicarboxylate is an azodicarboxylic acid derivative used as a reagent in the production of many organic compounds. Diisopropyl Azodicarboxylate is commonly used as an oxidizer in Mitsun
obu reactions and can also serve as a selective deprotectant of N-benzyl groups in the presence of other protecting groups.
3. Diisopropyl azodicarboxylate is used as an important reagent in the production of many organic compounds. It is used in association with triphenyl phosphine in Mitsunobu reaction of alcohols, acids and amides. It acts as reactant in the preparation of chromenes resembling classical cannabinoids, norbornene-based guanidine-rich polymers and acceptor-donor-acceptor organic dyes.
Chemical Properties
CLEAR ORANGE LIQUID
General Description
Reacted with dioxaphosphorinanes and iron catalyst to generate rearranged phosphonium ylide products.
Purification Methods
Purify the azo compound by distillation at as high a vacuum as possible. Since it is likely to explode, use an oil bath for heating the still, and all operations should be carried out behind an adequate shield. [Kauer Org Synth Coll Vol IV 412 1963, Beilstein 3 III 233]. This reagent is useful in the Mitsunobu reaction [Mitsunobu Synthesis 1 1981, Gennari et al. J Am Chem Soc 108 6394 1986, Evans et al. J Am Chem Soc 108 6394 1986, Hughes Org React 42 335 1992, Dodge et al. Org Synth 73 110 1996, Hughes Org Prep Proc Int 28 127 1996, Ferguson & Marcelle J Am Chem Soc 128 4576 2006; see also di-tert-butyl azodicarboxylate and DEAD above].
Check Digit Verification of cas no
The CAS Registry Mumber 2446-83-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,4 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2446-83:
(6*2)+(5*4)+(4*4)+(3*6)+(2*8)+(1*3)=85
85 % 10 = 5
So 2446-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H14N2O4/c1-5(2)13-7(11)9-10-8(12)14-6(3)4/h5-6H,1-4H3/b10-9+
2446-83-5Relevant articles and documents
Photocatalytic esterification under Mitsunobu reaction conditions mediated by flavin and visible light
M?rz,Chudoba,Kohout,Cibulka
supporting information, p. 1970 - 1975 (2017/03/11)
The usefulness of flavin-based aerial photooxidation in esterification under Mitsunobu reaction conditions was demonstrated, providing aerial dialkyl azodicarboxylate recycling/generation from the corresponding dialkyl hydrazine dicarboxylate. Simultaneously, activation of triphenylphosphine (Ph3P) by photoinduced electron transfer from flavin allows azo-reagent-free esterification. An optimized system with 3-methylriboflavin tetraacetate (10%), oxygen (terminal oxidant), visible light (450 nm), Ph3P, and dialkyl hydrazine dicarboxylate (10%) has been shown to provide efficient and stereoselective coupling of various alcohols and acids to esters with retention of configuration.
Method of manufacturing Azodicarboxylic acid diester compd. (by machine translation)
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Paragraph 0029-0031, (2017/04/28)
PROBLEM TO BE SOLVED: To provide a manufacturing method in which an azodicarboxylate diester compound can be efficiently obtained in a high yield and which is industrially advantageous.SOLUTION: There is provided a manufacturing method for azodicarboxylate diester compound including: a process (a) of obtaining a 1,2-hydrazine dicarboxylate diester compound through reaction between hydrazine and a halocarbonate ester; and a process (b) of obtaining an azodicarboxylate diester compound represented by general formula (2) (where A represents a hydrocarbon or a hydrocarbon which may have an ether bond) by oxidizing the 1,2-hydrazine dicarboxylate diester compound obtained in the process (a), the 1,2-hydrazine dicarboxylate diester compound being neither isolated nor refined.
HEPATITIS C VIRUS NS3 PROTEASE INHIBITORS
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, (2013/03/26)
The present invention relates to macrocyclic compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
