2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol

Base Information

• Chemical Name: 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol
• CAS No.: 1388892-17-8
• Molecular Formula: C₁₈H₂₈N₄OS
• Molecular Weight: 348.513
• Mol file: 1388892-17-8.mol

Synonyms:2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol

Chemical Property of 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol

There total 6 articles about 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

2-{[4-(dimethylamino)cyclohexyl]amino}ethan-1-ol hydrochloride + 4-chloro-6-ethylthieno<2,3-d>pyrimidine (81136-42-7) → 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol (1388892-17-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

benzyl N-[4-(dimethylamino)cyclohexyl]-N-(2-hydroxyethyl)carbamate (1388892-19-0) → 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol (1388892-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon / methanol / 20 °C

2: hydrogenchloride / dichloromethane / 3 h / 0 - 10 °C

3: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; potassium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

benzyl N-[4-(dimethylamino)cyclohexyl]carbamate (167298-51-3) → 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol (1388892-17-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: palladium 10% on activated carbon / methanol / 20 °C

3.1: hydrogenchloride / dichloromethane / 3 h / 0 - 10 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-amino-5-ethylthiophene-3-carboxylate

4-chloro-6-ethylthieno<2,3-d>pyrimidine

6-ethyl-3H-thieno[2,3-d]pyrimidin-4-one

benzyl N-[4-(dimethylamino)cyclohexyl]-N-(2-hydroxyethyl)carbamate