N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

Base Information

Chemical Name:N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide
CAS No.:1069094-45-6
Molecular Formula:C₁₇H₁₇Cl₂N₅O₃
Molecular Weight:410.26
Hs Code.:

Synonyms:N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

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Chemical Property of N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

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Technology Process of N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

There total 4 articles about N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.3%

: 1-[4-(methyloxy)-2-pyrimidinyl]-3-methyl-2-oxo-4-imidazolidinecarboxylic acid

: 95-00-1
2,4-dichloro-benzenemethanamine

: 1069094-45-6
N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: 1-[4-(methyloxy)-2-pyrimidinyl]-3-methyl-2-oxo-4-imidazolidinecarboxylic acid; In dichloromethane; at 20 ℃; for 0.0833333h; Molecular sieve;

With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;

2,4-dichloro-benzenemethanamine; In water-d2; at 20 ℃; for 4h;

Reference yield:

: 845543-47-7
(S)-tert-butyl 3-methyl-2-oxoimidazolidine-4-carboxylate

: 1069094-45-6
N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / Heating / reflux

2.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3.1: dichloromethane / 0.08 h / 20 °C / Molecular sieve

3.2: 0.17 h / 20 °C

3.3: 4 h / 20 °C

With caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

Reference yield:

: 845543-46-6
(S)-1-benzyl 4-tert-butyl 3-methyl-2-oxoimidazolidine-1,4-dicarboxylate

: 1069094-45-6
N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-[4-(methyloxy)-2-pyrimidinyl]-2-oxo-4-imidazolidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / Heating / reflux

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: dichloromethane / 0.08 h / 20 °C / Molecular sieve

4.2: 0.17 h / 20 °C

4.3: 4 h / 20 °C

With hydrogen; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane;