3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Base Information

Chemical Name:3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane
CAS No.:283168-36-5
Molecular Formula:C₂₃H₂₅F₃O₂
Molecular Weight:390.446
Hs Code.:

Synonyms:3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Suppliers and Price of 3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

There total 7 articles about 3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 87942-08-3
bromo(4-propylphenyl)magnesium

: 283168-35-4
3-hydroxy-3-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutan-3'-one

: 283168-36-5
3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Guidance literature:: DOI:10.1002/(sici)1521-3897(200004)342:4<409::aid-prac409>3.0.co;2-e

Reference yield:

: 66166-61-8
3-vinylcyclobutanone

: 283168-36-5
3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg / diethyl ether

1.2: 83 percent / diethyl ether / Heating

2.1: 80 percent / pyridine / diethyl ether / 0 °C

3.1: POCl₃; Zn/Cu couple / diethyl ether / 0 - 20 °C

4.1: AcOH; Zn / 70 - 80 °C

5.1: 65 percent

With pyridine; copper; magnesium; acetic acid; zinc; trichlorophosphate; In diethyl ether; 1.1: insertion / 1.2: Grignard reaction / 2.1: Silylation / 3.1: Cycloaddition / 4.1: Dehalogenation / 5.1: Grignard reaction;
DOI:10.1002/(sici)1521-3897(200004)342:4<409::aid-prac409>3.0.co;2-e

Reference yield:

: 31996-69-7
2,2-dichloro-3-vinylcyclobutanone

: 283168-36-5
3,3'-dihydroxy-3-(p-propylphenyl)-3'-(3'',4'',5''-trifluorophenyl)-1,1'-bicyclobutane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / AcOH; Zn / 2 h / 70 - 80 °C

2.1: Mg / diethyl ether

2.2: 83 percent / diethyl ether / Heating

3.1: 80 percent / pyridine / diethyl ether / 0 °C

4.1: POCl₃; Zn/Cu couple / diethyl ether / 0 - 20 °C

5.1: AcOH; Zn / 70 - 80 °C

6.1: 65 percent

With pyridine; copper; magnesium; acetic acid; zinc; trichlorophosphate; In diethyl ether; 1.1: Dehalogenation / 2.1: insertion / 2.2: Grignard reaction / 3.1: Silylation / 4.1: Cycloaddition / 5.1: Dehalogenation / 6.1: Grignard reaction;
DOI:10.1002/(sici)1521-3897(200004)342:4<409::aid-prac409>3.0.co;2-e