(5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone

Base Information

• Chemical Name: (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone
• CAS No.: 105526-90-7
• Molecular Formula: C₃₂H₃₇NO₃
• Molecular Weight: 483.651
• Mol file: 105526-90-7.mol

Synonyms:(5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone

Chemical Property of (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone

There total 22 articles about (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(5S)-N-[(2E)-but-2-enoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-86-1) → (5S)-N-[(3R)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-90-7) + (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-90-7) + (S)-4-((E)-But-2-enoylamino)-5-trityloxy-pentanoic acid

Guidance literature:

With chloro-trimethyl-silane; lithium di-n-butylcuprate; water; In diethyl ether; at -78 ℃; Yields of byproduct given;

DOI:10.1016/0040-4039(95)00336-B

Reference yield: 70.0%

(5S)-N-[(2E)-but-2-enoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-86-1) → (5S)-N-[(3R)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-90-7) + (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-90-7) + (S)-4-((E)-But-2-enoylamino)-5-trityloxy-pentanoic acid

Guidance literature:

With chloro-trimethyl-silane; lithium di-n-butylcuprate; water; In diethyl ether; at -78 ℃; Yields of byproduct given;

DOI:10.1016/0040-4039(95)00336-B

Reference yield: 70.0%

(5S)-N-[(2E)-but-2-enoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-86-1) → (5S)-N-[(3R)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-90-7) + (5S)-N-[(3S)-methylheptanoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone (105526-90-7) + (S)-4-((E)-But-2-enoylamino)-5-trityloxy-pentanoic acid

Guidance literature:

With chloro-trimethyl-silane; In diethyl ether; at -78 ℃; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(95)00336-B

upstream raw materials:

(5S)-N-[(2E)-but-2-enoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone

butyl magnesium bromide

(5S)-N-[(2E)-hept-2-enoyl]-5-triphenylmethoxymethyl-2-pyrrolidinone

n-butyl magnesium bromide

Downstream raw materials:

(-)-(S)-3-methylheptanoic acid

(R)-3-methylheptanoic acid