7-BROMO-BENZO[B]THIOPHENE

Base Information

• Chemical Name: 7-BROMO-BENZO[B]THIOPHENE
• CAS No.: 1423-61-6
• Molecular Formula: C8H5BrS
• Molecular Weight: 213.098
• Hs Code.: 29349990
• Mol file: 1423-61-6.mol

Synonyms:7-Bromobenzo[b]thiophene;7-Bromobenzothiophene;

Chemical Property of 7-BROMO-BENZO[B]THIOPHENE

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.704
• Boiling Point: 284.713 °C at 760 mmHg
• Flash Point: 125.99 °C
• PSA: 28.24000
• Density: 1.649 g/cm³
• LogP: 3.66380
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromobenzo[b]thiophene ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-BENZO[B]THIOPHENE

There total 11 articles about 7-BROMO-BENZO[B]THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(2-bromophenylthio) acetaldehyde diethyl acetal (137105-52-3) → 7-bromobenzo(b)thiophene (1423-61-6)

Guidance literature:

With PPA; In ethyl acetate; chlorobenzene; toluene;

Reference yield: 89.0%

1-bromo-2-((2,2-dimethoxyethyl)sulfanyl)benzene (799766-06-6) → 7-bromobenzo(b)thiophene (1423-61-6)

Guidance literature:

With PPA; In chlorobenzene; for 26.5h; Heating / reflux;

Reference yield: 76.0%

7-bromo-1-benzothiophene-2-carboxylic acid (19075-59-3) → 7-bromobenzo(b)thiophene (1423-61-6)

Guidance literature:

With acetic acid; silver carbonate; In dimethyl sulfoxide; at 120 ℃; for 16h;

DOI:10.1016/j.ejmech.2016.09.068

upstream raw materials:

1-bromo-2-((2,2-dimethoxyethyl)sulfanyl)benzene

2-(2-bromophenylthio) acetaldehyde diethyl acetal

o-bromothiophenol

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

benzo[b]thiophene-7-carbonitrile

7-(2-formylphenyl)benzo[b]thiophene

7-(2-formyl-4-methoxyphenyl)benzo[b]thiophene

2-(2-benzo[b]thiophen-7-yl-5-methoxy-phenyl)-oxirane

Refernces

• 1、 Hansen, Marvin M.,Clayton, Marcella T.,Godfrey, Alexander G.,Grutsch Jr., John L.,Keast, Sandra S.,Kohlman, Dan T.,McSpadden, Andreea R.,Pedersen, Steven W.,Ward, Jeffrey A.,Xu, Yao-Chang. "Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration". . p. 1351 - 1354. Retrieved 2004.
• 2、 -. "INHIBITORS OF THE KYNURENINE PATHWAY". Page/Page column 216; 217. . Retrieved 2014/12/12.