ALPHA-HYDROXY BENZENEHEPTANOIC ACID

Base Information

• Chemical Name: ALPHA-HYDROXY BENZENEHEPTANOIC ACID
• CAS No.: 103187-18-4
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Mol file: 103187-18-4.mol

Synonyms:7-Hydroxy-7-phenylheptanoicacid;Alpha-hydroxy benzeneheptanoic acid;Benzeneheptanoic acid, a-hydroxy-;

Chemical Property of ALPHA-HYDROXY BENZENEHEPTANOIC ACID

Chemical Property:

• Vapor Pressure: 2.97E-07mmHg at 25°C
• Refractive Index: 1.54
• Boiling Point: 404.1 °C at 760 mmHg
• PKA: 4.77±0.10(Predicted)
• Flash Point: 212.3 °C
• PSA: 57.53000
• Density: 1.124 g/cm³
• LogP: 2.23500

Purity/Quality:

98%Min ^*data from raw suppliers

2-Hydroxy-7-phenylheptanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-HYDROXY BENZENEHEPTANOIC ACID

There total 9 articles about ALPHA-HYDROXY BENZENEHEPTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

7-hydroxy-7-phenyl-heptanoic acid ethyl ester (112665-42-6) → 7-hydroxy-7-phenylheptanoic acid (103187-18-4,122114-99-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 70 ℃; for 3h;

DOI:10.1021/jm00129a030

Reference yield: 95.0%

→ 7-hydroxy-7-phenylheptanoic acid (103187-18-4,122114-99-2)

Guidance literature:

Reference yield: 65.0%

6-benzoylhexanoic acid (7472-43-7) → 7-hydroxy-7-phenylheptanoic acid (103187-18-4,122114-99-2)

Guidance literature:

With hydrido(phosphonite)cobalt(I); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In 2-methyltetrahydrofuran; for 16h; chemoselective reaction; Sealed tube; Irradiation; Schlenk technique;

DOI:10.1002/anie.202114482

upstream raw materials:

7-hydroxy-7-phenyl-heptanoic acid ethyl ester

ethyl 6-(chloroformyl)hexanoate

7-ethoxy-7-oxoheptanoic acid

ethyl 7-oxo-7-phenylheptanoate

Downstream raw materials:

7-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-7-phenyl-heptanoic acid

7-(2-hydroxy-3,4,6-trimethylphenyl)-7-phenylheptanoic acid

7-(3-Methyl-1,4-naphthoquinon-2-yl)-7-phenyl-heptanoic acid

p-nitrophenyl 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoate