112665-42-6

Basic information

• Product Name: 7-Hydroxy-7-phenylheptanoic acid ethyl ester
• Synonyms: 7-Hydroxy-7-phenylheptanoic acid ethyl ester;Ethyl 7-hydroxy-7-phenylheptanoate
• CAS NO: 112665-42-6
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.33338
• Mol File: 112665-42-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.045
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-Hydroxy-7-phenylheptanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxy-7-phenylheptanoic acid ethyl ester(112665-42-6)
• EPA Substance Registry System: 7-Hydroxy-7-phenylheptanoic acid ethyl ester(112665-42-6)

Safety Data

• Hazardous Substances Data: 112665-42-6(Hazardous Substances Data)

Upstream product

• 33018-91-6 7-ethoxy-7-oxoheptanoic acid 
• 14794-32-2 ethyl 6-(chloroformyl)hexanoate 
• 25542-62-5 6-bromo-hexanoic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 113274-32-1 C₈H₁₅IO₂Zn 
• 13159-24-5 ethyl 6-iodohexanoate 
• 112665-41-5 ethyl 7-oxo-7-phenylheptanoate 
• 122822-50-8 6-<(4-methylbenzenesulfonyl)oxy>hexanoic acid, ethyl ester 

Downstream Products

• 103186-19-2 (-)-AA 2414 
• 103187-09-3 (+)-AA 2414 
• 112665-43-7 seratrodast 
• 112665-40-4 p-nitrophenyl 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoate 
• 103186-54-5 7-(3-Methyl-1,4-naphthoquinon-2-yl)-7-phenyl-heptanoic acid 
• 148989-73-5 7-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-7-phenyl-heptanoic acid 
• 945414-47-1 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)-7-(triisopropylsilyloxy)heptan-1-one 
• 945414-46-0 7-phenyl-7-(triisopropylsilyloxy)heptanoic acid 
• 945414-45-9 ethyl 7-phenyl-7-(triisopropylsilyloxy)heptanoate 
• 103187-18-4 7-hydroxy-7-phenylheptanoic acid 

Relevant articles and documents

Indium-catalyzed synthesis of keto esters from cyclic 1,3-diketones and alcohols and application to the synthesis of seratrodast

Esterification reactions from cyclic 1,3-diketones and alcohols are carried out in the presence of several Lewis acids. In particular, indium(III) triflate, In(OTf)3, iron(III) triflate, Fe-(OTf)3, copper(II) triflate, Cu(OTf)2, and silver(I) triflate, AgOTf, show high catalytic activities. These reactions proceed through the carbon-carbon bond cleavage by a retro-aldol reaction and were found to be highly regioselective even in the presence of other functional groups. This type of reaction can also be applied to the preparation of the keto esters during the synthesis of seratrodast, which is an antiasthmatic and eicosanoid antagonist.

Takai-Utimoto reactions of oxoalkylhalides catalytic in chromium and cobalt

The scope of chromium(II)/cobalt(I)-catalyzed Takai-Utimoto reactions was extended to substrates with unprotected reactive functional groups. In the presence of a higher chlorosilane and manganese the first chromium(II)/cobalt(I)-catalyzed version for the

Quinones. 4. Novel eicosanoid antagonists: Synthesis and pharmacological evaluation

A new series of ω-phenyl-ω-quinonylalkanoic acids and related compounds was synthesized. The compounds were tested for their inhibitory effects on U-44069-induced contraction of the rabbit aorta. (±)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid (4d) (AA-2414) with pA2 value of 8.28 was one of the most potent compounds. Compound 4d inhibited U-46619-induced contraction of the guinea pig lung (pA2 = 8.29) and U-44069-induced aggregation of the guinea pig platelet (IC50 = 3.5 x 10-7 M). Compound 4d displaced the binding of [3H]U-46619 to guinea pig platelets (IC50 = 7.4 x 10-9 M). Compound 4d also showed very potent inhibitory effects with an MED of 0.3 mg/kg (po) on U-46619-, LTD4-, PAF-, or IgG1-induced bronchoconstriction in guinea pigs. The enantiomers of 4d were prepared. The R-(+) isomer 8a was active in both in vitro and in vivo tests, but the S-(-) isomer 8b was much less active. We concluded that the antiasthmatic effects of 4d were based mainly on the TXA2 receptor antagonistic action. In addition, compound 4d showed potent inhibitory effects on PGD2-, PGF(2α)-, and 11-epi-PGF(2α)-induced contraction of the guinea pig tracheal strips. The diverse inhibitory effects might be expressed in terms of eicosanoid-antagonistic activity.