1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

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Chemical Name:1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate
CAS No.:1025369-17-8
Molecular Formula:C₂₉H₃₂N₂O₆
Molecular Weight:504.583
Hs Code.:

Synonyms:1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

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Chemical Property of 1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

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Technology Process of 1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

There total 3 articles about 1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1000063-82-0
1-tert-butyl 2-methyl (2S,4R)-4-[(6-bromo-7-methoxy-2-phenylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

: potassium vinyltrifluoroborate

: 1025369-17-8
1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In ethanol; for 1.5h; Reflux;
DOI:10.1002/anie.200803298

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 1025369-17-8
1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / tetrahydrofuran; ethanol / 15 h / Reflux

2: pyridinium p-toluenesulfonate / dichloromethane / 20 h / Reflux

3: 0.5 h / 300 °C

4: caesium carbonate / 1-methyl-pyrrolidin-2-one / 15 h / 45 °C

5: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 1.5 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; pyridinium p-toluenesulfonate; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;

Reference yield:

: 914834-87-0
6-bromo-7-methoxy-2-phenylquinolin-4(1H)-one

: 438452-29-0
1-tert-butyl 2-methyl (2S,4S)-4-{[(4-bromo-phenyl)sulfonyl]oxy}-pyrrolidine-1,2-dicarboxylate

: 1025369-17-8
1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 15 h / 45 °C

2: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 1.5 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol;