(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate

Base Information

• Chemical Name: (1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate
• CAS No.: 1019771-53-9
• Molecular Formula: C₂₄H₂₈N₂O₃
• Molecular Weight: 392.498
• Mol file: 1019771-53-9.mol

Synonyms:(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate

Chemical Property of (1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate

There total 1 articles about (1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(-)-(R,R)-cyclopropane-1,2-dicarboxylic acid ethyl ester (613261-14-6) + diphenylmethylpiperazine (841-77-0) → (1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate (1019771-53-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃;

Reference yield: 86.0%

(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate (1019771-53-9) → (1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylic acid (1019771-54-0)

Guidance literature:

(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In water; pH=~ 3;

Reference yield: 44.0%

(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate (1019771-53-9) → (1R,2R)-(4-benzhydrylpiperazin-1-yl)(2-(hydroxymethyl)cyclopropyl)methanone (1019771-55-1)

Guidance literature:

(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate; With lithium borohydride; In tetrahydrofuran; methanol; at 20 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;

upstream raw materials:

(-)-(R,R)-cyclopropane-1,2-dicarboxylic acid ethyl ester

diphenylmethylpiperazine

Downstream raw materials:

(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylic acid

(1R,2R)-(4-benzhydrylpiperazin-1-yl)(2-(hydroxymethyl)cyclopropyl)methanone