1,2-Cyclopropanedicarboxylicacid,monoethylester,(1R,2R)-(9CI)

Base Information

• Chemical Name: 1,2-Cyclopropanedicarboxylicacid,monoethylester,(1R,2R)-(9CI)
• CAS No.: 613261-14-6
• Molecular Formula: C7H10O4
• Molecular Weight: 158.154
• Mol file: 613261-14-6.mol

Synonyms:1,2-Cyclopropanedicarboxylicacid,monoethylester,(1R,2R)-(9CI)

Chemical Property of 1,2-Cyclopropanedicarboxylicacid,monoethylester,(1R,2R)-(9CI)

Chemical Property:

• Melting Point: 58-60 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 130-134 °C(Press: 1.5 Torr)
• PKA: 4.14±0.11(Predicted)
• PSA: 63.60000
• Density: 1.322±0.06 g/cm3(Predicted)
• LogP: 0.27020

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Cyclopropanedicarboxylicacid,monoethylester,(1R,2R)-(9CI)

There total 4 articles about 1,2-Cyclopropanedicarboxylicacid,monoethylester,(1R,2R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1R,2R)-2-phenyl-cyclopropanecarboxylic acid ethyl ester (97-71-2,946-38-3,946-39-4,34702-96-0,34702-97-1,34703-00-9,34716-60-4,63038-62-0,63038-63-1) → (-)-(R,R)-cyclopropane-1,2-dicarboxylic acid ethyl ester (613261-14-6)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; at 20 ℃; for 72h;

DOI:10.1021/jo0344079

Reference yield: 90.0%

diethyl (-)-(1R,2R)-1,2-cyclopropanedicarboxylate (889461-58-9) → (-)-(R,R)-cyclopropane-1,2-dicarboxylic acid ethyl ester (613261-14-6)

Guidance literature:

diethyl (-)-(1R,2R)-1,2-cyclopropanedicarboxylate; With sodium hydroxide; water; In ethanol; at 20 ℃;

With hydrogenchloride; In water; pH=~ 2;

Reference yield: 49.0%

diethyl trans-cyclopropane-1,2-dicarboxylate (3999-55-1) → (-)-(R,R)-cyclopropane-1,2-dicarboxylic acid ethyl ester (613261-14-6) + (+)-(S,S)-cyclopropane-1,2-dicarboxylic acid diethyl ester (889461-57-8)

Guidance literature:

With water; sodium hydroxide; at 28 ℃; pH=7; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/b812777h

upstream raw materials:

(1R,2R)-2-phenyl-cyclopropanecarboxylic acid ethyl ester

diethyl (-)-(1R,2R)-1,2-cyclopropanedicarboxylate

diethyl trans-cyclopropane-1,2-dicarboxylate

Downstream raw materials:

ethyl (1R,2R)-2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate

ethyl (1R,2S)-2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate

ethyl (1S,2S)-2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate

(1R,2R)-ethyl 2-(4-benzhydrylpiperazin-1-carbonyl)cyclopropanecarboxylate