3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

Base Information

Chemical Name:3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one
CAS No.:645398-64-7
Molecular Formula:C₂₅H₂₉NO₅Se
Molecular Weight:502.469
Hs Code.:

Synonyms:3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

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Chemical Property of 3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

Chemical Property:

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Technology Process of 3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

There total 5 articles about 3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 645398-63-6
3-(benzyloxycarbonyl)-3-(phenylselanyl)piperidin-2-one

: 645398-64-7
3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1021/jo035151+

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 645398-64-7
3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

1.3: 93 percent / tetrahydrofuran / 0.5 h / -78 °C

2.1: 63 percent / TFA / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 96 percent / TBAB; K₂CO₃ / acetonitrile / 24 h / 20 °C

With tetrabutylammomium bromide; potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo035151+

Reference yield:

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 645398-64-7
3-(benzyloxycarbonyl)-1-[(tert-butoxycarbonyl)methyl]-3-(phenylselanyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

1.3: 93 percent / tetrahydrofuran / 0.5 h / -78 °C

2.1: 63 percent / TFA / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 96 percent / TBAB; K₂CO₃ / acetonitrile / 24 h / 20 °C

With tetrabutylammomium bromide; potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo035151+