N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

Base Information

Chemical Name:N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide
CAS No.:182289-38-9
Molecular Formula:C₁₄H₁₃ClF₃N₃O₂S
Molecular Weight:379.79
Hs Code.:

Synonyms:N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

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Chemical Property of N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

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Technology Process of N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

There total 6 articles about N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenylamine

: 182289-38-9
N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

Guidance literature:: In acetonitrile; Heating;
DOI:10.1021/jf9601978

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 182289-38-9
N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C / ethanol / 15 h / 2585.7 Torr

2: 3 h / Heating

3: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

4: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

5: 76 percent / magnesium monoperoxyphthallic acid / acetic acid

6: aq. AcOH, Fe / 0.5 h / 80 °C

7: 79 percent / acetonitrile / Heating

With hydrogenchloride; tert.-butylnitrite; magnesium monoperoxyphthallic acid; sulfuric acid; hydrogen; nitric acid; iron; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; acetic acid; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jf9601978

Reference yield:

: 535-52-4
2-fluoro-5-(trifluoromethyl)aniline

: 182289-38-9
N-[5-(4-Chloro-1-methyl-5-methylsulfanyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 3 h / Heating

2: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

3: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

4: 76 percent / magnesium monoperoxyphthallic acid / acetic acid

5: aq. AcOH, Fe / 0.5 h / 80 °C

6: 79 percent / acetonitrile / Heating

With hydrogenchloride; tert.-butylnitrite; magnesium monoperoxyphthallic acid; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; In acetic acid; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jf9601978