535-52-4

Usage

Uses

Used in Chemical Synthesis Studies:
2-Fluoro-5-(trifluoromethyl)aniline is used as a chemical intermediate for the synthesis of various compounds, particularly in the pharmaceutical and agrochemical industries. Its unique structure allows for the creation of novel molecules with potential applications in drug development and crop protection.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Fluoro-5-(trifluoromethyl)aniline is used as a building block for the development of new drugs. Its specific functional groups enable the formation of diverse chemical entities that can target specific biological pathways, potentially leading to the discovery of innovative therapeutics.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2-Fluoro-5-(trifluoromethyl)aniline serves as a key intermediate for the synthesis of new pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, contributing to improved crop yields and food security.

InChI:InChI=1/C7HClF4O2/c8-2-3(9)1(7(13)14)4(10)6(12)5(2)11/h(H,13,14)

Upstream product

• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 402-44-8 4-Fluorobenzotrifluoride 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 352-32-9 p-fluorotoluene 
• 402-42-6 4-fluoro-1-trichloromethylbenzene 
• 7439-89-6 iron 
• 98-16-8 3-trifluoromethylaniline 
• 588-00-1 1,2-bis(3-(trifluoromethyl)phenyl)diazene 

Downstream Products

• 349-27-9 N-(2-fluoro-5-(trifluoromethyl)phenyl)acetamide 
• 1799-82-2 N-<2-Fluor-5-trifluormethyl-phenyl>-carbamidsaeure-ethylester 
• 2284-87-9 N-<2-Fluor-5-trifluormethyl-phenyl>-carbamidsaeureisopropylester 
• 58140-17-3 C₁₆H₇F₈N₅ 
• 143925-49-9 2-phenyl-5-(trifluoromethyl)benzo[d]oxazole 
• 143925-52-4 N-(2-Fluoro-phenyl)-4-methoxy-benzamide 
• 86844-83-9 (1S,2R,6S,7R)-4-(2-Fluoro-5-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione 
• 87126-67-8 3-(2-Fluoro-5-trifluoromethyl-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid 
• 32137-20-5 1-chloro-2-fluoro-4-(trifluoromethyl)benzene 
• 300561-25-5 N-(2-fluoro-5-trifluoromethylphenyl)methanesulfonamide 
• 260045-47-4 2-chloro-4-(2-fluoro-5-trifluoromethylanilino)pyrimidine 
• 939807-34-8 N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea 
• 796967-62-9 N-(2-fluoro-5-trifluoromethylphenyl)-N'-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)phenyl]urea 
• 948313-33-5 2-[4-(3-amino-4-nitrophenoxy)phenyl]-N-(2-fluoro-5-trifluoromethylphenyl)acetamide 

Relevant academic research and scientific papers

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

Synthesis of 2 - fluoro aniline compounds of the method

The invention discloses a method for synthesizing 2 - fluoro aniline compounds of the method, the method is: shown in formula Ia aniline compound of formula Ib α and β shown aniline compound as raw materials, through coupling reaction shown [...] azobenzene compound II, then the type II shown azobenzene compound with a palladium catalyst, fluorination reagent, additive, organic solvent, in the 30 - 150 °C temperature closed agitating the fluorination reaction, [...] compound of formula III, type III compounds are shown in the reaction under the action of a reducing [...] shown IV 2 - fluoro aniline compounds; this invention synthetic 2 - fluoro aniline compounds substrate wide adaptability, mild reaction conditions, the operation is simple, fluorinated and good selectivity, [...] aniline compounds is prepared by many drug molecule is an important intermediate and starting material, wide application prospects.

Torsional and Electronic Factors Control the C?H???O Interaction

The precise role of non-conventional hydrogen bonds such as the C?H???O interaction in influencing the conformation of small molecules remains unresolved. Here we survey a series of β-turn mimetics using X-ray crystallography and NMR spectroscopy in conju

ANILINE DERIVATIVE HAVING ANTI-RNA VIRAL ACTIVITY

Viruses, and particularly RNA viruses, have high mutation rates. Hence, antiviral agents that have been developed to date targeting protease or reverse transcriptase of viruses have quickly lost their effectiveness and resistant viruses have emerged. Also

CYANOMETHYLENE COMPOUNDS, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL OR HORTICULTURAL BACTERICIDE

The cyanomethylene compound of the invention is a compound represented by the formula (1) wherein R is C1-20 straight-chain or branched-chain alkyl, C3-8 cycloalkyl, aryl or heterocyclic group; and the aryl and the heterocyclic group

Synthesis and QSAR of Herbicidal 3-Pyrazolyl α,α,α-Trifluorotolyl Ethers

Pyrazole nitrophenyl ethers (PPEs) were recently identified as a novel class of chemistry exerting herbicidal effects by inhibition of protoporphyrinogen IX oxidase. This area of chemistry has been extended to include herbicidal pyrazolyl fluorotolyl ethe